| Autor: |
Friedman MA; Division of Cancer Treatment, National Cancer Institute, Bethesda, MD., Phillips TL, Hannigan JF Jr, Carter SK |
| Jazyk: |
angličtina |
| Zdroj: |
NCI monographs : a publication of the National Cancer Institute [NCI Monogr] 1988 (6), pp. 259-64. |
| Abstrakt: |
The effects of iv or intra-arterial chemotherapy added to hepatic irradiation were evaluated in a 3-arm randomized trial. Patients with predominantly hepatic metastases or with hepatoma were eligible. They were randomized to receive 2,100 cGy in seven fractions alone or with 5-fluorouracil given either intra-arterially or by iv infusion; doxorubicin and mitomycin were given by bolus simultaneously with the radiation in a single course. A total of 166 patients were entered in the study. Toxicity was acceptable, with no sign of enhanced radiation damage. Response was evaluated 4-6 weeks after treatment. No complete responses were seen, but partial responses greater than or equal to 50% were observed in the groups treated with radiation only (17%), radiation plus drug given iv (25%), and radiation plus drug given intra-arterially (20%) (P greater than .3). Disease progression occurred in a larger number of patients who received radiation only (29%) at 6 weeks than in the other 2 groups (7% and 18%, respectively; P less than .03). Thus, in terms of local response duration, the addition of chemotherapy enhanced the effect of the radiation. Survival was not different among the 3 groups. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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