| Autor: |
Oltmans GA; Department of Pharmacology, University of Health Sciences, Chicago Medical School, IL 60064., Moss LE, Lorden JF, Beales M |
| Jazyk: |
angličtina |
| Zdroj: |
Brain research [Brain Res] 1987 Dec 22; Vol. 437 (1), pp. 183-8. |
| DOI: |
10.1016/0006-8993(87)91543-5 |
| Abstrakt: |
The neurotoxin 3-acetylpyridine was administered to 20-day-old rats to produce lesions of the inferior olive-climbing fiber projection to the cerebellum. Cerebellar cGMP levels were determined 6 h, 24 h, 48 h, 7 days, 14 days and 20 days postlesion. A significant effect on cGMP was found only at 48 h (-28%) and 7 days (-45%) postlesion. The results are discussed with respect to the cellular localization of cGMP and the hypothesized relationship of cGMP to cerebellar Purkinje cell activity. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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