Characterisation of musculoskeletal tumours by multivoxel proton MR spectroscopy.

Autor: Patni RS; Department of Radio-diagnosis, Assam Medical College, Dibrugarh, Assam, India., Boruah DK; Department of Radio-diagnosis, Assam Medical College, Dibrugarh, Assam, India. drdeb_rad@yahoo.co.in.; M-Lane, RCC-4, Assam Medical College Campus, Dibrugarh, Assam, 786002, India. drdeb_rad@yahoo.co.in., Sanyal S; Consultant Radiologist, Airedale General Hospital, West Yorkshire, UK., Gogoi BB; Department of Pathology, NEIGHRMS, Shillong, Meghalaya, India., Patni M; Department of Anesthesiology, Geetanjali Medical College, Udaipur, Rajasthan, India., Khandelia R; Department of Pathology, Assam Medical College, Dibrugarh, Assam, India., Gogoi N; Department of Radio-diagnosis, Assam Medical College, Dibrugarh, Assam, India.
Jazyk: angličtina
Zdroj: Skeletal radiology [Skeletal Radiol] 2017 Apr; Vol. 46 (4), pp. 483-495. Date of Electronic Publication: 2017 Feb 11.
DOI: 10.1007/s00256-017-2573-1
Abstrakt: Objective: The purpose of this study is to evaluate the role of multi-voxel proton MR spectroscopy in differentiating benign and malignant musculoskeletal tumours in a more objective way and to correlate the MRS data parameters with histopathology.
Methods and Materials: A hospital-based prospective study was carried out comprising 42 patients who underwent MRI examinations from 1 July 2013 to 30 June 2014. After routine sequences, single-slice multi-voxel proton MR spectroscopy was included at TE-135 using the PRESS sequence. The voxel with the maximum choline/Cr ratio was used for analysis of data in 32 patients. The strength of association between the MR spectroscopy findings and the nature of tumour and histopathological grading were assessed.
Results: Of the 42 patients, the MR spectra were not of diagnostic quality in 10. In the remaining 32 patients, 12 (37.5%) had benign and 20 (62.5%) malignant tumours. The mean choline/Cr ratio was 6.97 ± 5.95 (SD) for benign tumours and 25.39 ± 17.72 (SD) for malignant tumours. In our study statistical significance was noted between the choline/Cr ratio and the histological nature of musculoskeletal tumours (p = 0.002) assessed by unpaired t-test. The choline/Cr ratio and histological grading were also found to be significant (p = 0.001) when assessed by one-way ANOVA test.
Conclusions: Multi-voxel MR spectroscopy showed a higher choline/Cr ratio in malignant musculoskeletal tumours than in benign ones (p = 0.002). The choline/Cr ratio and histological grading of musculoskeletal tumours also showed statistical significance (p = 0.001).
Databáze: MEDLINE
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