[Therapeutic drug monitoring of three antiepileptic drugs - Back on twenty years of experience].

Autor: Serragui S; Laboratoire de Pharmacologie et de Toxicologie, Faculté de Médecine et de Pharmacie, Université Mohammed V, Rabat, Maroc., Zalagh F; Centre Anti Poison et de Pharmacovigilance du Maroc., Tanani DS; Laboratoire de Pharmacologie Faculté de Médecine et de Pharmacie, Université Abdelmalek Essaadi, Tanger, Maroc., Ouammi L; Centre Anti Poison et de Pharmacovigilance du Maroc., Moussa LA; Centre Anti Poison et de Pharmacovigilance du Maroc., Badrane N; Centre Anti Poison et de Pharmacovigilance du Maroc., Bencheikh RS; Laboratoire de Pharmacologie et de Toxicologie, Faculté de Médecine et de Pharmacie, Université Mohammed V, Rabat, Maroc; Centre Anti Poison et de Pharmacovigilance du Maroc.
Jazyk: francouzština
Zdroj: The Pan African medical journal [Pan Afr Med J] 2016 Sep 19; Vol. 25, pp. 10. Date of Electronic Publication: 2016 Sep 19 (Print Publication: 2016).
DOI: 10.11604/pamj.2016.25.10.9664
Abstrakt: Introduction: The therapeutic drug monitoring (TDM) of antiepileptic drugs is a tool widely used in the management of epilepsy. In Morocco, this monitoring is carried out by the Centre Anti Poison et Pharmacovigilance (CAPM) since April 1995.
Methods: This is a retrospective study spanning 20 years. It concerns the therapeutic drug monitoring of Phenobarbital (PB) of carbamazepine (CBZ) and valproic acid (VPA).
Results: Therapeutic drug monitoring of the 3 antiepileptic drugs represent 58.85% of all applications received by the CAPM. The dosage of PB was ranked first followed by that of CBZ and finally by the VPA. Weak demand for therapeutic drug monitoring in Morocco could be explained by the low number of neurologists in addition to social factors. With its affordable price by patients, PB is the most prescribed antiepileptic drug in our country, which explains the high demand for its dosage. As for the therapeutic drug monitoring of the antiepileptic drug, they were mainly related to age, the occurrence of adverse effects, the association antiepileptic drugs or in the case of verification of patient compliance.
Conclusion: Efforts are required for promoting the interests of therapeutic drug monitoring of antiepileptic drug in the management of epilepsy in Morocco.
Competing Interests: Conflits d’intérêts Les auteurs ne déclarent aucun conflit d'intérêts.
Databáze: MEDLINE
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