Plasma L-carnitine levels of obese and non-obese polycystic ovary syndrome patients.

Autor:	Celik F; a Faculty of Medicine, Department of Obstetrics and Gynecology , Afyon Kocatepe University , Afyonkarahisar , Turkey., Kose M; a Faculty of Medicine, Department of Obstetrics and Gynecology , Afyon Kocatepe University , Afyonkarahisar , Turkey., Yilmazer M; a Faculty of Medicine, Department of Obstetrics and Gynecology , Afyon Kocatepe University , Afyonkarahisar , Turkey., Köken GN; a Faculty of Medicine, Department of Obstetrics and Gynecology , Afyon Kocatepe University , Afyonkarahisar , Turkey., Arioz DT; a Faculty of Medicine, Department of Obstetrics and Gynecology , Afyon Kocatepe University , Afyonkarahisar , Turkey., Kanat Pektas M; a Faculty of Medicine, Department of Obstetrics and Gynecology , Afyon Kocatepe University , Afyonkarahisar , Turkey.
Jazyk:	angličtina
Zdroj:	Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology [J Obstet Gynaecol] 2017 May; Vol. 37 (4), pp. 476-479. Date of Electronic Publication: 2017 Jan 31.
DOI:	10.1080/01443615.2016.1264375
Abstrakt:	It is well-known that plasma L-carnitine concentrations are significantly decreased in obese individuals. A study showed that L-carnitine concentrations are significantly lower in lean PCOS patients than in lean healthy women. Thus, it has been suggested that lowered L-carnitine is associated with PCOS. This study also showed that the women with PCOS had significantly lower L-carnitine levels than those of the healthy controls. In addition, this study hypothesised that low L-carnitine levels in PCOS patients were associated with obesity and/or insulin resistance. Moreover, plasma L-carnitine concentrations were found to be statistically similar in PCOS patients and healthy controls, when controlled for obesity. This study implied that L-carnitine could be used as an adjunctive therapy in the management of insulin resistance or obesity in women who have PCOS. Further research might be planned to clarify the clinical effects of L-carnitine administration in PCOS patients with insulin resistance and/or obesity.
Databáze:	MEDLINE
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