On the ecosystemic network of saliva in healthy young adults.

Autor: Zaura E; Top Institute Food and Nutrition, Wageningen, The Netherlands.; Department of Preventive Dentistry, Academic Centre for Dentistry Amsterdam, University of Amsterdam and Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., Brandt BW; Top Institute Food and Nutrition, Wageningen, The Netherlands.; Department of Preventive Dentistry, Academic Centre for Dentistry Amsterdam, University of Amsterdam and Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., Prodan A; Top Institute Food and Nutrition, Wageningen, The Netherlands.; Department of Oral Biochemistry, Academic Centre for Dentistry Amsterdam, University of Amsterdam and Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., Teixeira de Mattos MJ; Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, The Netherlands., Imangaliyev S; Top Institute Food and Nutrition, Wageningen, The Netherlands.; Department of Preventive Dentistry, Academic Centre for Dentistry Amsterdam, University of Amsterdam and Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Research Group Microbiology and Systems Biology, TNO Earth, Life and Social Sciences, Zeist, The Netherlands., Kool J; Top Institute Food and Nutrition, Wageningen, The Netherlands.; Research Group Microbiology and Systems Biology, TNO Earth, Life and Social Sciences, Zeist, The Netherlands., Buijs MJ; Top Institute Food and Nutrition, Wageningen, The Netherlands.; Department of Preventive Dentistry, Academic Centre for Dentistry Amsterdam, University of Amsterdam and Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., Jagers FL; Top Institute Food and Nutrition, Wageningen, The Netherlands.; Research Group Microbiology and Systems Biology, TNO Earth, Life and Social Sciences, Zeist, The Netherlands., Hennequin-Hoenderdos NL; Department of Periodontology, Academic Centre for Dentistry Amsterdam, University of Amsterdam and Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., Slot DE; Department of Periodontology, Academic Centre for Dentistry Amsterdam, University of Amsterdam and Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., Nicu EA; Department of Periodontology, Academic Centre for Dentistry Amsterdam, University of Amsterdam and Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., Lagerweij MD; Department of Cariology, Endodontology, Pedodontology, Academic Centre for Dentistry Amsterdam, University of Amsterdam and Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., Janus MM; Top Institute Food and Nutrition, Wageningen, The Netherlands.; Department of Preventive Dentistry, Academic Centre for Dentistry Amsterdam, University of Amsterdam and Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., Fernandez-Gutierrez MM; Top Institute Food and Nutrition, Wageningen, The Netherlands.; Department of Animal Sciences, Host-Microbe Interactomics Group, Wageningen University, Wageningen, The Netherlands., Levin E; Top Institute Food and Nutrition, Wageningen, The Netherlands.; Research Group Microbiology and Systems Biology, TNO Earth, Life and Social Sciences, Zeist, The Netherlands., Krom BP; Top Institute Food and Nutrition, Wageningen, The Netherlands.; Department of Preventive Dentistry, Academic Centre for Dentistry Amsterdam, University of Amsterdam and Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., Brand HS; Top Institute Food and Nutrition, Wageningen, The Netherlands.; Department of Oral Biochemistry, Academic Centre for Dentistry Amsterdam, University of Amsterdam and Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., Veerman EC; Department of Oral Biochemistry, Academic Centre for Dentistry Amsterdam, University of Amsterdam and Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., Kleerebezem M; Top Institute Food and Nutrition, Wageningen, The Netherlands.; Department of Animal Sciences, Host-Microbe Interactomics Group, Wageningen University, Wageningen, The Netherlands., Loos BG; Department of Periodontology, Academic Centre for Dentistry Amsterdam, University of Amsterdam and Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., van der Weijden GA; Department of Periodontology, Academic Centre for Dentistry Amsterdam, University of Amsterdam and Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., Crielaard W; Top Institute Food and Nutrition, Wageningen, The Netherlands.; Department of Preventive Dentistry, Academic Centre for Dentistry Amsterdam, University of Amsterdam and Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., Keijser BJ; Top Institute Food and Nutrition, Wageningen, The Netherlands.; Department of Preventive Dentistry, Academic Centre for Dentistry Amsterdam, University of Amsterdam and Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Research Group Microbiology and Systems Biology, TNO Earth, Life and Social Sciences, Zeist, The Netherlands.
Jazyk: angličtina
Zdroj: The ISME journal [ISME J] 2017 May; Vol. 11 (5), pp. 1218-1231. Date of Electronic Publication: 2017 Jan 10.
DOI: 10.1038/ismej.2016.199
Abstrakt: A dysbiotic state is believed to be a key factor in the onset of oral disease. Although oral diseases have been studied for decades, our understanding of oral health, the boundaries of a healthy oral ecosystem and ecological shift toward dysbiosis is still limited. Here, we present the ecobiological heterogeneity of the salivary ecosystem and relations between the salivary microbiome, salivary metabolome and host-related biochemical salivary parameters in 268 healthy adults after overnight fasting. Gender-specific differences in the microbiome and metabolome were observed and were associated with salivary pH and dietary protein intake. Our analysis grouped the individuals into five microbiome and four metabolome-based clusters that significantly related to biochemical parameters of saliva. Low salivary pH and high lysozyme activity were associated with high proportions of streptococcal phylotypes and increased membrane-lipid degradation products. Samples with high salivary pH displayed increased chitinase activity, higher abundance of Veillonella and Prevotella species and higher levels of amino acid fermentation products, suggesting proteolytic adaptation. An over-specialization toward either a proteolytic or a saccharolytic ecotype may indicate a shift toward a dysbiotic state. Their prognostic value and the degree to which these ecotypes are related to increased disease risk remains to be determined.
Databáze: MEDLINE
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