Changes in patterns of uveitis at a tertiary referral center in Northern Italy: analysis of 990 consecutive cases.

Autor: Luca C; Immunology Eye Unit, Eye Department, Arcispedale S. M. Nuova-IRCCS, Reggio Emilia, Italy. cimino.luca@asmn.re.it., Raffaella A; Department of Clinical and Experimental Medicine, University of Parma, Parma, Italy., Sylvia M; Immunology Eye Unit, Eye Department, Arcispedale S. M. Nuova-IRCCS, Reggio Emilia, Italy.; Eye Department, Arcispedale S. M. Nuova-IRCCS, Reggio Emilia, Italy., Valentina M; Immunology Eye Unit, Eye Department, Arcispedale S. M. Nuova-IRCCS, Reggio Emilia, Italy.; Eye Department, Arcispedale S. M. Nuova-IRCCS, Reggio Emilia, Italy., Fabiana V; Immunology Eye Unit, Eye Department, Arcispedale S. M. Nuova-IRCCS, Reggio Emilia, Italy., Marco C; Eye Department, Arcispedale S. M. Nuova-IRCCS, Reggio Emilia, Italy., Annamaria S; Immunology Eye Unit, Eye Department, Arcispedale S. M. Nuova-IRCCS, Reggio Emilia, Italy.; Eye Department, Arcispedale S. M. Nuova-IRCCS, Reggio Emilia, Italy., Luisa S; Scientific Directorate, Arcispedale S.M. Nuova-IRCCS, Reggio Emilia, Italy., Alessandro F; Department of Pediatrics, Arcispedale S. M. Nuova.IRCCS, Reggio Emilia, Italy., Lucia B; Clinical Immunology, Allergy and Advanced Biotechnologies Unit, Arcispedale Santa Maria Nuova-IRCCS, Reggio Emilia, Italy., Alessandro Z; Clinical Immunology, Allergy and Advanced Biotechnologies Unit, Arcispedale Santa Maria Nuova-IRCCS, Reggio Emilia, Italy., Maria P; Clinical Immunology, Allergy and Advanced Biotechnologies Unit, Arcispedale Santa Maria Nuova-IRCCS, Reggio Emilia, Italy., Matthew C; Wits Reproductive Health and HIV Institute, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Alessandra S; Rheumatology Unit, Department of Internal Medicine, Arcispedale S. M. Nuova-IRCCS, Reggio Emilia, Italy., Carlo S; Rheumatology Unit, Department of Internal Medicine, Arcispedale S. M. Nuova-IRCCS, Reggio Emilia, Italy., Luigi F; Eye Department, Arcispedale S. M. Nuova-IRCCS, Reggio Emilia, Italy.
Jazyk: angličtina
Zdroj: International ophthalmology [Int Ophthalmol] 2018 Feb; Vol. 38 (1), pp. 133-142. Date of Electronic Publication: 2017 Jan 09.
DOI: 10.1007/s10792-016-0434-x
Abstrakt: Purpose: The role of uveitis, an uncommon ocular disease, is often neglected in research and treatment of autoimmune conditions. The study described the spectrum of uveitis at a referral center in North Italy, and compared that to a previously published series of patients.
Methods: We reviewed all patients with uveitis diagnosed from 2013 to 2015 at the Immunology Eye Unit, Arcispedale S. M. Nuova-IRCCS, Reggio Emilia, Italy. We examined patient characteristics, disease spectrum, and etiologies.
Results: In total, 990 cases of uveitis were identified, who were mostly female (59%) with a median age at presentation of 44 years (interquartile range = 29-57). Anterior uveitis was most frequent (53.5%), followed by panuveitis (22.8%), posterior (16.2%), and intermediate uveitis (5.5%). Anterior herpetic uveitis (15.6%), Fuchs uveitis (9.7%), and HLA-B27 positive anterior uveitis (7.7%) were the most common specific diagnoses. Compared with the previous series, we observed an increased incidence of uveitis, and a different pattern of diagnoses. Rates of herpetic, HLA-B27 positive uveitis, and presumed ocular tuberculosis were higher, but Fuchs uveitis was less frequent.
Conclusions: The pattern of uveitis appears to be changing, very likely due to population-level increases in infectious diseases, to the availability of new diagnostic tests and to the interdisciplinary approach used in patient diagnosis.
Databáze: MEDLINE
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