Proteinuria during dengue fever in children.

Autor:	Andries AC; Institut Pasteur in Cambodia, International Network of Pasteur Institutes, Virology Unit, Phnom Penh, Cambodia., Duong V; Institut Pasteur in Cambodia, International Network of Pasteur Institutes, Virology Unit, Phnom Penh, Cambodia., Cappelle J; Institut Pasteur in Cambodia, International Network of Pasteur Institutes, Epidemiology and Public Health Unit, Phnom Penh, Cambodia; Centre de coopération internationale en recherche agronomique pour le développement (CIRAD), Département ES, Unité AGIRs, Montpellier, France., Ong S; Institut Pasteur in Cambodia, International Network of Pasteur Institutes, Virology Unit, Phnom Penh, Cambodia., Kerleguer A; Institut Pasteur in Cambodia, International Network of Pasteur Institutes, Medical laboratory, Phnom Penh, Cambodia., Ly S; Institut Pasteur in Cambodia, International Network of Pasteur Institutes, Epidemiology and Public Health Unit, Phnom Penh, Cambodia., Tarantola A; Institut Pasteur in Cambodia, International Network of Pasteur Institutes, Epidemiology and Public Health Unit, Phnom Penh, Cambodia., Horwood PF; Institut Pasteur in Cambodia, International Network of Pasteur Institutes, Virology Unit, Phnom Penh, Cambodia., Sakuntabhai A; Institut Pasteur, Functional Genetics of Infectious Diseases Unit, Paris, France; Centre National de la Recherche Scientifique, Unité de recherche Associée 3012, Paris, France., Dussart P; Institut Pasteur in Cambodia, International Network of Pasteur Institutes, Virology Unit, Phnom Penh, Cambodia., Buchy P; Institut Pasteur in Cambodia, International Network of Pasteur Institutes, Virology Unit, Phnom Penh, Cambodia; GlaxoSmithKline, Vaccines R&D, Scientific Affairs and Public Health, Singapore. Electronic address: philippe.x.buchy@gsk.com.
Jazyk:	angličtina
Zdroj:	International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases [Int J Infect Dis] 2017 Feb; Vol. 55, pp. 38-44. Date of Electronic Publication: 2016 Dec 28.
DOI:	10.1016/j.ijid.2016.12.022
Abstrakt:	Objectives: This study aimed to investigate proteinuria occurring during dengue disease in children and assess if measurement of this parameter can help physicians in the clinical management of patients. Methods: Proteinuria was assessed by dipstick and quantified by urine protein:creatinine ratio (UPCR) in samples from patients hospitalized with a confirmed dengue infection and in healthy controls. Results: The dipstick tested positive in 42.9% of the patients presenting at hospital with dengue versus 20.0% in healthy controls. UPCR increased during the critical phase of the disease; peaking one week after fever onset then decreasing as the patients recovered. Patients with warnings signs or severe dengue were more likely to present with proteinuria detected by UPCR at the time of hospital admission compared to patients without warning signs. The sensitivity of this marker, however, was limited as only 16.1% of the patients with warning signs had proteinuria. Conclusions: Urine dipstick and UPCR do not seem to be very valuable for the triage of the patients at the time of the initial consultation but the observation of a decrease of the UPCR during the course of the illness appears to indicate an evolution towards recovery. (Copyright © 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Databáze:	MEDLINE
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