| Autor: |
Bagus Wasito E; Department of Microbiology, Faculty of Medicine, Airlangga University/Dr. Soetomo Hospital.; Institute of Tropical Disease, Airlangga University., Shigemura K; Department of Urology, Kobe University Graduate School of Medicine.; Indonesia-Japan Collaborative Research Center for Emerging and Re-emerging Infectious Diseases, Institute of Tropical Disease, Airlangga University.; Division of Infectious Diseases, Department of International Health, Kobe University Graduate School of Health Science., Osawa K; Indonesia-Japan Collaborative Research Center for Emerging and Re-emerging Infectious Diseases, Institute of Tropical Disease, Airlangga University.; Division of Infectious Diseases, Department of International Health, Kobe University Graduate School of Health Science., Fardah A; Department of Pediatrics, Faculty of Medicine, Airlangga University., Kanaida A; Division of Infectious Diseases, Department of International Health, Kobe University Graduate School of Health Science., Raharjo D; Indonesia-Japan Collaborative Research Center for Emerging and Re-emerging Infectious Diseases, Institute of Tropical Disease, Airlangga University.; Institute of Tropical Disease, Airlangga University., Kuntaman K; Department of Microbiology, Faculty of Medicine, Airlangga University/Dr. Soetomo Hospital.; Indonesia-Japan Collaborative Research Center for Emerging and Re-emerging Infectious Diseases, Institute of Tropical Disease, Airlangga University., Hadi U; Department of Internal Medicine, Faculty of Medicine, Airlangga University/Dr. Soetomo Hospital., Harijono S; Indonesia-Japan Collaborative Research Center for Emerging and Re-emerging Infectious Diseases, Institute of Tropical Disease, Airlangga University.; Institute of Tropical Disease, Airlangga University., Marto Sudarmo S; Department of Pediatrics, Faculty of Medicine, Airlangga University., Nakamura T; Department of Clinical Laboratory, Kobe University Hospital., Shibayama K; Department of Bacteriology II, National Institute of Infectious Diseases., Fujisawa M; Department of Urology, Kobe University Graduate School of Medicine., Shirakawa T; Indonesia-Japan Collaborative Research Center for Emerging and Re-emerging Infectious Diseases, Institute of Tropical Disease, Airlangga University.; Center for Infectious Diseases, Kobe University Graduate School of Medicine. |
| Abstrakt: |
The purpose of this study was to investigate extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli isolates from pediatric (aged 0 to 3 years) diarrhea patients in Surabaya, Indonesia, where this kind of survey is rare; our study included assessment of their antibiotic susceptibilities, as well as ESBL typing, multilocus sequence typing (MLST), and diarrheagenic E. coli (DEC)-typing. ESBL-producing E. coli were detected in 18.8% of all the samples. Many ESBL-producing E. coli had significantly lower susceptibility to gentamicin (p ＜ 0.0001) and the quinolones nalidixic acid (p＝0.004) and ciprofloxacin (p ＜ 0.0001) than non-producers. In ESBL-producing E. coli, 84.0% of strains expressed CTX-M-15 alone or in combination with other ESBL types. MLST revealed that 24.0% of ESBL-producers had sequence type 617, all of which expressed the CTX-M-15 gene; we also detected expression of 3 DEC-related genes: 2 enteroaggregative E. coli genes and 1 enteropathogenic E. coli gene. In conclusion, CTX-M-15-type ESBL-producing E. coli ST617 appear to have spread to Indonesia. |
