Directional Fluid Transport across Organ-Blood Barriers: Physiology and Cell Biology.
| Autor: | Caceres PS; Margaret Dyson Vision Research Institute, Department of Ophthalmology, Weill Cornell Medical College, New York, New York 10065., Benedicto I; Margaret Dyson Vision Research Institute, Department of Ophthalmology, Weill Cornell Medical College, New York, New York 10065., Lehmann GL; Margaret Dyson Vision Research Institute, Department of Ophthalmology, Weill Cornell Medical College, New York, New York 10065., Rodriguez-Boulan EJ; Margaret Dyson Vision Research Institute, Department of Ophthalmology, Weill Cornell Medical College, New York, New York 10065. |
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| Jazyk: | angličtina |
| Zdroj: | Cold Spring Harbor perspectives in biology [Cold Spring Harb Perspect Biol] 2017 Mar 01; Vol. 9 (3). Date of Electronic Publication: 2017 Mar 01. |
| DOI: | 10.1101/cshperspect.a027847 |
| Abstrakt: | Directional fluid flow is an essential process for embryo development as well as for organ and organism homeostasis. Here, we review the diverse structure of various organ-blood barriers, the driving forces, transporters, and polarity mechanisms that regulate fluid transport across them, focusing on kidney-, eye-, and brain-blood barriers. We end by discussing how cross talk between barrier epithelial and endothelial cells, perivascular cells, and basement membrane signaling contribute to generate and maintain organ-blood barriers. (Copyright © 2017 Cold Spring Harbor Laboratory Press; all rights reserved.) |
| Databáze: | MEDLINE |
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