Vitamin D Deficiency in Patients Referred for Evaluation of Obstructive Sleep Apnea.

Autor:	Salepci B; University of Medical Sciences İstanbul, Kartal Dr. Lutfi Kirdar Teaching and Research Hospital, Chest Diseases Clinic, Istanbul, Turkey., Caglayan B; İstanbul, Koç University Medical Faculty, Chest Diseases Clinic, Istanbul, Turkey., Nahid P; University of California, San Francisco, San Francisco General Hospital, Division of Pulmonary and Critical Care Medicine, San Francisco, California., Parmaksiz ET; University of Medical Sciences İstanbul, Kartal Dr. Lutfi Kirdar Teaching and Research Hospital, Chest Diseases Clinic, Istanbul, Turkey., Kiral N; University of Medical Sciences İstanbul, Kartal Dr. Lutfi Kirdar Teaching and Research Hospital, Chest Diseases Clinic, Istanbul, Turkey., Fidan A; University of Medical Sciences İstanbul, Kartal Dr. Lutfi Kirdar Teaching and Research Hospital, Chest Diseases Clinic, Istanbul, Turkey., Comert SS; University of Medical Sciences İstanbul, Kartal Dr. Lutfi Kirdar Teaching and Research Hospital, Chest Diseases Clinic, Istanbul, Turkey., Dogan C; University of Medical Sciences İstanbul, Kartal Dr. Lutfi Kirdar Teaching and Research Hospital, Chest Diseases Clinic, Istanbul, Turkey., Gungor GA; University of Medical Sciences İstanbul, Kartal Dr. Lutfi Kirdar Teaching and Research Hospital, Chest Diseases Clinic, Istanbul, Turkey.
Jazyk:	angličtina
Zdroj:	Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine [J Clin Sleep Med] 2017 Apr 15; Vol. 13 (4), pp. 607-612. Date of Electronic Publication: 2017 Apr 15.
DOI:	10.5664/jcsm.6554
Abstrakt:	Study Objectives: A recent study reported an association between obstructive sleep apnea (OSA) and low vitamin D levels. In this study, we measured vitamin D levels in patients referred for evaluation of suspected OSA and sought to identify associated risk factors for vitamin D deficiency. Our objective was to determine whether evaluations of patients with suspected OSA should include routine screening for vitamin D deficiency. Methods: Using a cross-sectional study design, we measured vitamin D levels in consecutively enrolled patients referred for an OSA evaluation to Dr. Lutfi Kirdar Kartal Training and Research Hospital in Istanbul, Turkey. We conducted full-night polysomnography and compared vitamin D levels both between patients with OSA and patients without OSA and across the various severity levels of OSA. We evaluated the association between vitamin D levels and various clinical and demographic characteristics, including the apnea-hypopnea index and body mass index. Results: From April 2014 to June 2015, 195 patients were referred for OSA evaluation. Of these, 181 patients (93%) consented to participate and underwent full polysomnography and measurement of vitamin D levels. The mean ± standard deviation age was 49 ± 12 years and body mass index of 31 ± 6 kg/m 2 . Polysomnography led to the diagnosis of OSA in 162 of the patients (89.5%): 52 (32%) were categorized as having mild OSA, 38 (23.5%) as having moderate OSA, and 72 (44.5%) as having severe OSA. Vitamin D level was 15.5 ± 11.6 ng/mL (95% confidence interval; 13-17 ng/mL) and 134 patients (74%) met the criterion for vitamin D deficiency (< 20 ng/mL). Sex, vitamin D levels, and percentage of patients with vitamin D deficiency were similar in patients with and without OSA ( P > .05). Vitamin D levels were similar across OSA severity categories ( P = .68). We found no association between vitamin D levels and the apnea-hypopnea index or body mass index. Conclusion: A large proportion of patients referred for OSA evaluation had vitamin D deficiency. Vitamin D levels did not differ by OSA diagnosis status or severity. Patients referred for polysomnography should undergo routine screening for vitamin D deficiency as well as clinically indicated treatment to prevent associated comorbidities. (© 2017 American Academy of Sleep Medicine)
Databáze:	MEDLINE
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