Cerebral Microvascular and Systemic Effects Following Intravenous Administration of the Perfluorocarbon Emulsion Perftoran.

Autor:	Abutarboush R; NeuroTrauma Department, Naval Medical Research Center (NMRC), Silver Spring, MD 20910, USA. rania.abutarboush.ctr@mail.mil., Saha BK; NeuroTrauma Department, Naval Medical Research Center (NMRC), Silver Spring, MD 20910, USA. biswajit.k.saha.ctr@mail.mil., Mullah SH; NeuroTrauma Department, Naval Medical Research Center (NMRC), Silver Spring, MD 20910, USA. saad.h.mullah.ctr@mail.mil., Arnaud FG; NeuroTrauma Department, Naval Medical Research Center (NMRC), Silver Spring, MD 20910, USA. francoise.arnaud.ctr@mail.mil.; Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD 20895, USA. francoise.arnaud.ctr@mail.mil., Haque A; NeuroTrauma Department, Naval Medical Research Center (NMRC), Silver Spring, MD 20910, USA. ashraful.haque.ctr@mail.mil., Aligbe C; NeuroTrauma Department, Naval Medical Research Center (NMRC), Silver Spring, MD 20910, USA. chioma.aligbe@med.navy.mil., Pappas G; NeuroTrauma Department, Naval Medical Research Center (NMRC), Silver Spring, MD 20910, USA. georgina.pappas@quinnipiac.edu., Auker CR; NeuroTrauma Department, Naval Medical Research Center (NMRC), Silver Spring, MD 20910, USA. charles.auker.ctr@mail.mil., McCarron RM; NeuroTrauma Department, Naval Medical Research Center (NMRC), Silver Spring, MD 20910, USA. richard.m.mccarron.civ@mail.mil.; Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD 20895, USA. richard.m.mccarron.civ@mail.mil., Moon-Massat PF; NeuroTrauma Department, Naval Medical Research Center (NMRC), Silver Spring, MD 20910, USA. pfmoonmassat@outlook.com., Scultetus AH; NeuroTrauma Department, Naval Medical Research Center (NMRC), Silver Spring, MD 20910, USA. anke.h.scultetus2.ctr@mail.mil.; Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD 20895, USA. anke.h.scultetus2.ctr@mail.mil.
Jazyk:	angličtina
Zdroj:	Journal of functional biomaterials [J Funct Biomater] 2016 Nov 18; Vol. 7 (4). Date of Electronic Publication: 2016 Nov 18.
DOI:	10.3390/jfb7040029
Abstrakt:	Oxygen-carrying perfluorocarbon (PFC) fluids have the potential to increase tissue oxygenation during hypoxic states and to reduce ischemic cell death. Regulatory approval of oxygen therapeutics was halted due to concerns over vasoconstrictive side effects. The goal of this study was to assess the potential vasoactive properties of Perftoran by measuring brain pial arteriolar diameters in a healthy rat model. Perftoran, crystalloid (saline) or colloid (Hextend) solutions were administered as four sequential 30 min intravenous (IV) infusions, thus allowing an evaluation of cumulative dose-dependent effects. There were no overall changes in diameters of small-sized (<50 μm) pial arterioles within the Perftoran group, while both saline and Hextend groups exhibited vasoconstriction. Medium-sized arterioles (50-100 μm) showed minor (~8-9%) vasoconstriction within saline and Hextend groups and only ~5% vasoconstriction within the Perftoran group. For small- and medium-sized pial arterioles, the mean percent change in vessel diameters was not different among the groups. Although there was a tendency for arterial blood pressures to increase with Perftoran, pressures were not different from the other two groups. These data show that Perftoran, when administered to healthy anesthetized rats, does not cause additional vasoconstriction in cerebral pial arterioles or increase systemic blood pressure compared with saline or Hextend. Competing Interests: The authors declare no conflict of interest. The views expressed in this article are those of the authors and do not necessarily reflect the official policy or position of the Department of the Navy, Department of Defense, nor the U.S. Government. Authors are military service members (or an employee of the U.S. Government). This work was prepared as part of their official duties. Title 17 USC §105 provides that “copyright protection under this title is not available for any work of the U.S. Government”. Title 17 USC §101 defines a U.S. Government work as a work prepared by a military service member or employee of the U.S. Government as part of that person’s official duties.
Databáze:	MEDLINE
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