From Anthramycin to Pyrrolobenzodiazepine (PBD)-Containing Antibody-Drug Conjugates (ADCs).
Autor: | Mantaj J; Institute of Pharmaceutical Science, King's College London, Britannia House, 7 Trinity Street, London SE1 1DB, and Femtogenix Ltd, Britannia House, 7 Trinity Street, London, SE1 1DB, UK., Jackson PJ; Institute of Pharmaceutical Science, King's College London, Britannia House, 7 Trinity Street, London SE1 1DB, and Femtogenix Ltd, Britannia House, 7 Trinity Street, London, SE1 1DB, UK., Rahman KM; Institute of Pharmaceutical Science, King's College London, Britannia House, 7 Trinity Street, London SE1 1DB, and Femtogenix Ltd, Britannia House, 7 Trinity Street, London, SE1 1DB, UK., Thurston DE; Professor of Drug Discovery, King's College London, Faculty of Life Sciences & Medicine, Institute of Pharmaceutical Science, Britannia House, 7 Trinity Street, London, SE1 1DB, UK.; Femtogenix Ltd, Britannia House, 7 Trinity Street, London, SE1 1DB, UK. |
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Jazyk: | angličtina |
Zdroj: | Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2017 Jan 09; Vol. 56 (2), pp. 462-488. Date of Electronic Publication: 2016 Nov 15. |
DOI: | 10.1002/anie.201510610 |
Abstrakt: | The pyrrolo[2,1-c][1,4]benzodiazepines (PBDs) are a family of sequence-selective DNA minor-groove binding agents that form a covalent aminal bond between their C11-position and the C2-NH (© 2016 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA.) |
Databáze: | MEDLINE |
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