Effectiveness of agomelatine on anhedonia in depressed patients: an outpatient, open-label, real-world study.

Autor: Gargoloff PD; Hospital Alejandro Korn, Melchor Romero, La Plata, Argentina.; Clinica City Bell, La Plata, Argentina., Corral R; Departamento de Docencia e Investigacion, Hospital Jose T Borda, CABA, Argentina., Herbst L; Hospital Jose T. Borda, CABA, Argentina., Marquez M; ADINEU, CABA, Argentina., Martinotti G; Department of Neuroscience, Imaging and Clinical Science, Chieti, Italy., Gargoloff PR; Clinica City Bell, La Plata, Argentina.
Jazyk: angličtina
Zdroj: Human psychopharmacology [Hum Psychopharmacol] 2016 Nov; Vol. 31 (6), pp. 412-418.
DOI: 10.1002/hup.2557
Abstrakt: Objective: The aim of this real-world study was to evaluate the effect of agomelatine on anhedonia as primary endpoint in outpatients under treatment of major depressive episodes.
Methods: The study was an open-label, multicenter, 8-week phase IV trial. Two hundred fifty-seven (257) patients were recruited, and 143 patients were included in the analysis. Agomelatine was administered orally as a 25-mg tablet. The dose could be increased to 50 mg after 2 weeks of treatment.
Results: An improvement in the severity of anhedonia (Snaith-Hamilton Pleasure Scale total score) was observed from 8.5 points at baseline to 4.1 at week 8, statistically significant (p < 0.05) from the first week. Significant decreases in scores on the severity of depression (Quick Inventory of Depressive Symptomatology 16-item Self-Report [QIDS-SR-16]), anxiety (Generalized Anxiety Disorder 7-item scale), and in overall clinical status (CGI) were also found over 8 weeks, independently from the presence of a first or recurrence episode. Response (QIDS-SR-16 score ≥ 50% of baseline) at week 8 was observed in 65.7% of the patients, while 49.6% of the patients achieved remission (QIDS-SR-16 score ≤ 5).
Conclusion: Agomelatine was shown to be effective on anhedonia, depression, and anxiety in subjects with major depression. The pragmatic design of the study reflects real-world clinical practice providing interesting insights into routine care management.
(Copyright © 2016 John Wiley & Sons, Ltd.)
Databáze: MEDLINE
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