Parallel processing by cortical inhibition enables context-dependent behavior.

Autor: Kuchibhotla KV; Skirball Institute, Neuroscience Institute, Departments of Otolaryngology, Neuroscience and Physiology, New York University School of Medicine, New York, New York, USA.; Center for Neural Science, New York University, New York, New York, USA., Gill JV; Skirball Institute, Neuroscience Institute, Departments of Otolaryngology, Neuroscience and Physiology, New York University School of Medicine, New York, New York, USA.; Center for Neural Science, New York University, New York, New York, USA., Lindsay GW; Center for Theoretical Neuroscience, Department of Neuroscience, Swartz Program in Theoretical Neuroscience, Kavli Institute for Brain Science, Columbia University, New York, New York, USA., Papadoyannis ES; Skirball Institute, Neuroscience Institute, Departments of Otolaryngology, Neuroscience and Physiology, New York University School of Medicine, New York, New York, USA.; Center for Neural Science, New York University, New York, New York, USA., Field RE; Skirball Institute, Neuroscience Institute, Departments of Otolaryngology, Neuroscience and Physiology, New York University School of Medicine, New York, New York, USA.; Center for Neural Science, New York University, New York, New York, USA., Sten TA; Skirball Institute, Neuroscience Institute, Departments of Otolaryngology, Neuroscience and Physiology, New York University School of Medicine, New York, New York, USA.; Center for Neural Science, New York University, New York, New York, USA., Miller KD; Center for Theoretical Neuroscience, Department of Neuroscience, Swartz Program in Theoretical Neuroscience, Kavli Institute for Brain Science, Columbia University, New York, New York, USA., Froemke RC; Skirball Institute, Neuroscience Institute, Departments of Otolaryngology, Neuroscience and Physiology, New York University School of Medicine, New York, New York, USA.; Center for Neural Science, New York University, New York, New York, USA.
Jazyk: angličtina
Zdroj: Nature neuroscience [Nat Neurosci] 2017 Jan; Vol. 20 (1), pp. 62-71. Date of Electronic Publication: 2016 Oct 31.
DOI: 10.1038/nn.4436
Abstrakt: Physical features of sensory stimuli are fixed, but sensory perception is context dependent. The precise mechanisms that govern contextual modulation remain unknown. Here, we trained mice to switch between two contexts: passively listening to pure tones and performing a recognition task for the same stimuli. Two-photon imaging showed that many excitatory neurons in auditory cortex were suppressed during behavior, while some cells became more active. Whole-cell recordings showed that excitatory inputs were affected only modestly by context, but inhibition was more sensitive, with PV + , SOM + , and VIP + interneurons balancing inhibition and disinhibition within the network. Cholinergic modulation was involved in context switching, with cholinergic axons increasing activity during behavior and directly depolarizing inhibitory cells. Network modeling captured these findings, but only when modulation coincidently drove all three interneuron subtypes, ruling out either inhibition or disinhibition alone as sole mechanism for active engagement. Parallel processing of cholinergic modulation by cortical interneurons therefore enables context-dependent behavior.
Competing Interests: The authors have no competing financial interests.
Databáze: MEDLINE
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