Synthesis and antimalarial activity of N-benzylated (N-arylcarbamoyl)alkylphosphonic acid derivatives.

Autor: Adeyemi CM; Department of Chemistry, Rhodes University, Grahamstown 6140, South Africa., Faridoon; Department of Chemistry, Rhodes University, Grahamstown 6140, South Africa., Isaacs M; Centre for Chemico- and Biomedicinal Research, Rhodes University, Grahamstown 6140, South Africa., Mnkandhla D; Centre for Chemico- and Biomedicinal Research, Rhodes University, Grahamstown 6140, South Africa., Hoppe HC; Department of Biochemistry and Microbiolgy, Rhodes University, Grahamstown 6140, South Africa; Centre for Chemico- and Biomedicinal Research, Rhodes University, Grahamstown 6140, South Africa., Krause RW; Department of Chemistry, Rhodes University, Grahamstown 6140, South Africa; Centre for Chemico- and Biomedicinal Research, Rhodes University, Grahamstown 6140, South Africa., Kaye PT; Department of Chemistry, Rhodes University, Grahamstown 6140, South Africa; Centre for Chemico- and Biomedicinal Research, Rhodes University, Grahamstown 6140, South Africa. Electronic address: P.Kaye@ru.ac.za.
Jazyk: angličtina
Zdroj: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2016 Dec 01; Vol. 24 (23), pp. 6131-6138. Date of Electronic Publication: 2016 Apr 09.
DOI: 10.1016/j.bmc.2016.04.021
Abstrakt: A series of novel and readily accessible N-benzylated (N-arylcarbamoyl)alkylphosphonate esters and related compounds have been prepared as potential antimalarial agents. Bioassays reveal that some of these compounds exhibit promising activity against Plasmodium falciparum, and exhibit no significant growth inhibition of HeLa cells.
(Copyright © 2016. Published by Elsevier Ltd.)
Databáze: MEDLINE
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