Good Outcomes in Kidney Transplantation With Deceased Donor With Acute Kidney Injury: Donor's Age and Not Acute Kidney Injury Predicts Graft Function.

Autor: Si Nga H; Department of Internal Medicine-UNESP, Universidade Estadual Paulista, Botucatu, São Paulo, Brazil., Takase HM; Department of Internal Medicine-UNESP, Universidade Estadual Paulista, Botucatu, São Paulo, Brazil., Bravin AM; Department of Internal Medicine-UNESP, Universidade Estadual Paulista, Botucatu, São Paulo, Brazil., Garcia PD; Department of Internal Medicine-UNESP, Universidade Estadual Paulista, Botucatu, São Paulo, Brazil., Contti MM; Department of Internal Medicine-UNESP, Universidade Estadual Paulista, Botucatu, São Paulo, Brazil., Kojima CA; Department of Internal Medicine-UNESP, Universidade Estadual Paulista, Botucatu, São Paulo, Brazil., de Andrade LG; Department of Internal Medicine-UNESP, Universidade Estadual Paulista, Botucatu, São Paulo, Brazil. Electronic address: landrade@fmb.unesp.br.
Jazyk: angličtina
Zdroj: Transplantation proceedings [Transplant Proc] 2016 Sep; Vol. 48 (7), pp. 2262-2266.
DOI: 10.1016/j.transproceed.2016.06.004
Abstrakt: Background: With the increased demand for kidney transplants and the short supply of organs, it is necessary to have a better strategy to evaluate the available organs, especially from donors with acute kidney injury (AKI), because these organs are often rejected for transplantation.
Methods: We evaluated patients undergoing transplantation with kidneys from deceased donors with AKI. The cases were divided into AKI stages according to the Acute Kidney Injury Network (AKIN) criteria. The outcomes examined were delayed graft function (DGF), creatinine (Cr), and creatinine clearance (CrCl) at 6 months after transplantation.
Results: We evaluated 101 patients and included 53 in the final model. There was no statistical difference in the demographic characteristics, comorbidities, and immunosuppression according to each AKIN stage, showing a population of homogeneous transplant recipients. Recipients in AKIN stages I, II, and III, respectively had DGF in 72.7%, 61.9%, and 71.4% of cases; Cr of 1.6 ± 0.5, 1.7 ± 0.7, and 1.6 ± 0.2 mg/dL at 6 months; and CrCl of 60.6 ± 22.4, 52.4 ± 27.4, and 52.03 ± 12.1 mL/min at 6 months. Each additional year in donor age increased the relative risk of DGF by 1.08 (1.0-1.13) (P = .01), and organs from older donors were associated with worse renal function at 6 months.
Conclusion: Kidney transplantation of organs from deceased donors with AKI showed greater DGF but good outcomes. Donor age was the only characteristic that correlated with outcome.
(Copyright © 2016 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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