| Autor: |
Hesselink JM; University of Witten/Herdecke, Witten, Germany., Chiosi F; Eye Clinic, Department of Medicine and Health Sciences, University of Molise, Campobasso, Italy., Costagliola C; Eye Clinic, Department of Medicine and Health Sciences, University of Molise, Campobasso, Italy. |
| Jazyk: |
angličtina |
| Zdroj: |
Drug design, development and therapy [Drug Des Devel Ther] 2016 Sep 27; Vol. 10, pp. 3133-3141. Date of Electronic Publication: 2016 Sep 27 (Print Publication: 2016). |
| DOI: |
10.2147/DDDT.S112389 |
| Abstrakt: |
Resolvins are a novel class of lipid-derived endogenous molecules (autacoids) with potent immunomodulating properties, which regulate the resolution phase of an active immune response. These modulating factors are locally produced, influencing the function of cells and/or tissues, which are produced on demand and subsequently metabolized in the same cells and/or tissues. This review is focused on certain lipid autacoids with putative relevance for ophthalmology in general and for dry eye more specifically. We also briefly investigate the concept of aliamides and the role of palmitoylethanolamide in ophthalmology, and analyze in more detail the putative role and the preclinical and clinical development of resolvins as emerging treatments for dry eye and related disorders, with a focus on one of the lead resolvin derivatives - RX-10045. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
