Nanohybride Materials Based on Magnetite-Gold Nanoparticles for Diagnostics of Prostate Cancer: Synthesis and In Vitro Testing.

Autor: Machulkin AE; Laboratory of Tissue-Specific Ligands, Faculty of Chemistry, M. V. Lomonosov Moscow State University, Moscow, Russia. alekseymachulkin@rambler.ru.; Laboratory of Biomedical Nanomaterials, National University of Science and Technology, Moscow Institute of Steel and Alloys (NUST MISiS), Moscow, Russia. alekseymachulkin@rambler.ru., Garanina AS; Laboratory of Biomedical Nanomaterials, National University of Science and Technology, Moscow Institute of Steel and Alloys (NUST MISiS), Moscow, Russia., Zhironkina OA; Department of Electronic Microscopy, A. N. Belozersky Research Institute of Physical and Chemical Biology, Moscow, Russia., Beloglazkina EK; Laboratory of Tissue-Specific Ligands, Faculty of Chemistry, M. V. Lomonosov Moscow State University, Moscow, Russia.; Laboratory of Biomedical Nanomaterials, National University of Science and Technology, Moscow Institute of Steel and Alloys (NUST MISiS), Moscow, Russia., Zyk NV; Laboratory of Tissue-Specific Ligands, Faculty of Chemistry, M. V. Lomonosov Moscow State University, Moscow, Russia., Savchenko AG; Laboratory of Biomedical Nanomaterials, National University of Science and Technology, Moscow Institute of Steel and Alloys (NUST MISiS), Moscow, Russia., Kotelyanskii VE; Laboratory of Tissue-Specific Ligands, Faculty of Chemistry, M. V. Lomonosov Moscow State University, Moscow, Russia., Mazhuga AG; Laboratory of Tissue-Specific Ligands, Faculty of Chemistry, M. V. Lomonosov Moscow State University, Moscow, Russia.; Laboratory of Biomedical Nanomaterials, National University of Science and Technology, Moscow Institute of Steel and Alloys (NUST MISiS), Moscow, Russia.
Jazyk: angličtina
Zdroj: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2016 Sep; Vol. 161 (5), pp. 706-710. Date of Electronic Publication: 2016 Oct 04.
DOI: 10.1007/s10517-016-3490-3
Abstrakt: We synthesized a fluorescence conjugate and modified magnetite-gold nanoparticles carrying prostate specific membrane antigen (PSMA) as the ligand. Analysis of their binding to human prostate cancer cell lines PC-3 (PSMA - ) and LNCaP (PSMA + ) showed selective interaction of the synthesized conjugate and modified nanoparticles with LNCaP cells. These findings suggest that these nanoparticles can be used in tissue-specific magnetic-resonance imaging.
Databáze: MEDLINE
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