Traumatic brain injury and subsequent glioblastoma development: Review of the literature and case reports.

Autor:	Tyagi V; Department of Orthopaedics and Rehabilitation, Yale University School of Medicine, New Haven, CT, USA., Theobald J; Department of Neurosurgery, NYU School of Medicine, Brooklyn, New York, USA., Barger J; Department of Neurosurgery, NYU School of Medicine, Brooklyn, New York, USA., Bustoros M; Department of Neurosurgery, NYU School of Medicine, Brooklyn, New York, USA., Bayin NS; Department of Neurosurgery, NYU School of Medicine, Brooklyn, New York, USA; Kimmel Center for Stem Cell Biology, NYU School of Medicine, Brooklyn, New York, USA., Modrek AS; Department of Neurosurgery, NYU School of Medicine, Brooklyn, New York, USA., Kader M; Department of Neurosurgery, NYU School of Medicine, Brooklyn, New York, USA., Anderer EG; Division of Neurosurgery, Maimonides Medical Center, Brooklyn, New York, USA., Donahue B; Department of Radiation Oncology, NYU School of Medicine, Brooklyn, New York, USA; Maimonides Cancer Center, Brooklyn, New York, USA., Fatterpekar G; Department of Radiology, NYU School of Medicine, Brooklyn, New York, USA., Placantonakis DG; Department of Neurosurgery, NYU School of Medicine, Brooklyn, New York, USA; Kimmel Center for Stem Cell Biology, NYU School of Medicine, Brooklyn, New York, USA; Brain Tumor Center, NYU School of Medicine, Brooklyn, New York, USA.
Jazyk:	angličtina
Zdroj:	Surgical neurology international [Surg Neurol Int] 2016 Aug 26; Vol. 7, pp. 78. Date of Electronic Publication: 2016 Aug 26 (Print Publication: 2016).
DOI:	10.4103/2152-7806.189296
Abstrakt:	Background: Previous reports have proposed an association between traumatic brain injury (TBI) and subsequent glioblastoma (GBM) formation. Methods: We used literature searches and radiographic evidence from two patients to assess the possibility of a link between TBI and GBM. Results: Epidemiological studies are equivocal on a possible link between brain trauma and increased risk of malignant glioma formation. We present two case reports of patients with GBM arising at the site of prior brain injury. Conclusion: The hypothesis that TBI may predispose to gliomagenesis is disputed by several large-scale epidemiological studies, but supported by some. Radiographic evidence from two cases presented here suggest that GBM formed at the site of brain injury. We propose a putative pathogenesis model that connects post-traumatic inflammation, stem and progenitor cell transformation, and gliomagenesis.
Databáze:	MEDLINE
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