Idiopathic delayed-onset edema surrounding deep brain stimulation leads: Insights from a case series and systematic literature review.

Autor: de Cuba CM; Department of Neurosurgery, Academic Medical Center, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands., Albanese A; Department of Neurology, Istituto Neurologico Carlo Besta, Via Giovanni Celoria 11, 20133, Milan, Italy; Department of Neurology, Istituto Clinico Humanitas, Via Alessandro Manzoni 113, Rozzano, Milano, Italy., Antonini A; UO Parkinson -IRCCS San Camillo, Via Alberoni 70, 30126, Venice, Italy., Cossu G; Neurology Unit, Brotzu General Hospital, Piazzale Ricchi 1, Cagliari, Italy., Deuschl G; Department of Neurology, Universitätsklinik Schleswig-Holstein, Christian-Albrechts University, Christian-Albrechts-Platz 4, 24118, Kiel, Germany., Eleopra R; Neurological Unit, S. Maria della Misericordia University Hospital, Piazzale Santa Maria della Misericordia 15, Udine, Italy., Galati A; Department of Neurosurgery, Prof. Dr. Bernardo A. Houssay Hospital, Pres. Hipólito Yrigoyen 1757, Buenos Aires, Argentina., Hoffmann CF; Department of Neurosurgery, Haga Teaching Hospital, Leyweg 275, 2545 CH, The Hague, The Netherlands., Knudsen K; Department of Neurology, Universitätsklinik Schleswig-Holstein, Christian-Albrechts University, Christian-Albrechts-Platz 4, 24118, Kiel, Germany., Landi A; Department of Neurosurgery, San Gerardo Hospital, Via Giambattista Pergolesi 33, 20052, Monza, Italy., Lanotte MM; Department of Neuroscience, University of Turin, Via Cherasco 15, Turin, Italy., Marcante A; UO Parkinson -IRCCS San Camillo, Via Alberoni 70, 30126, Venice, Italy., Mosch A; Department of Neurology, Haga Teaching Hospital, Leyweg 275, 2545 CH, The Hague, The Netherlands., Pilleri M; UO Parkinson -IRCCS San Camillo, Via Alberoni 70, 30126, Venice, Italy; UF Neurologia Casa di Cura Villa Margherita, Via Costacolonna 6, 36057, Vicenza, Italy., Reich MM; Department of Neurology, University Clinic of Würzburg, Josef-Schneider-Str. 11, 97080, Würzburg, Germany., Ricchi V; Neurology Unit, Brotzu General Hospital, Piazzale Ricchi 1, Cagliari, Italy., Rinaldo S; Neurological Unit, S. Maria della Misericordia University Hospital, Piazzale Santa Maria della Misericordia 15, Udine, Italy., Romito LM; Department of Neurology, Istituto Neurologico Carlo Besta, Via Giovanni Celoria 11, 20133, Milan, Italy., Saba FS; Department of Neurology, Istituto Neurologico Carlo Besta, Via Giovanni Celoria 11, 20133, Milan, Italy; Departmento de neurociências en ciências do comportamento, Universidade de São Paulo, Faculdade de Medicina de Riberão Preto - Serviço de Neurocirurgia Funcional, Hospital do Coração, R. Abílio Soares, 250 - Paraíso, São Paulo, SP, 04005-000, Brazil., Sacristan HE; Department of Neurology, Prof. Dr. Bernardo A. Houssay Hospital, Pres. Hipólito Yrigoyen 1757, Buenos Aires, Argentina., Schuurman PR; Department of Neurosurgery, Academic Medical Center, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands., Trezza A; Department of Neurosurgery, San Gerardo Hospital, Via Giambattista Pergolesi 33, 20052, Monza, Italy., van den Munckhof P; Department of Neurosurgery, Academic Medical Center, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands., Volkmann J; Department of Neurology, University Clinic of Würzburg, Josef-Schneider-Str. 11, 97080, Würzburg, Germany., Zibetti M; Department of Neuroscience, University of Turin, Via Cherasco 15, Turin, Italy., Contarino MF; Department of Neurology, Haga Teaching Hospital, Leyweg 275, 2545 CH, The Hague, The Netherlands; Department of Neurology, Leiden University Medical Centre, Albinusdreef 2, 2333 ZA Leiden, The Netherlands. Electronic address: m.f.contarino@lumc.nl.
Jazyk: angličtina
Zdroj: Parkinsonism & related disorders [Parkinsonism Relat Disord] 2016 Nov; Vol. 32, pp. 108-115. Date of Electronic Publication: 2016 Sep 06.
DOI: 10.1016/j.parkreldis.2016.09.007
Abstrakt: Introduction: Deep brain stimulation (DBS) is effective for some neurological and psychiatric conditions. Idiopathic delayed-onset edema (IDE) surrounding the leads has been anecdotally reported. The etiology, predisposing factors and prognosis of this complication are unknown. We present a multicenter case series of patients with IDE, and a systematic literature review, aimed at defining the pathophysiology and identifying appropriate treatment strategies.
Methods: IDE was defined as edema along the DBS lead, occurring ≥72 h postoperatively, in absence of trauma, vascular events or infection. Information on patients with IDE was collected in a standardized way. A systematic search was performed in Pubmed.
Results: Twelve new patients presenting with 14 episodes of IDE are described. From the literature, 38 patients were identified. No common surgical aspects or patient-related factors were identified as risk predictors for the onset of IDE. Symptoms included deterioration of the stimulation effect, seizures and focal neurological signs. Although the condition is self-limiting, with symptoms resolution in 28.5 days on average, three patients underwent surgical revision and seven received antibiotics.
Conclusions: IDE is a rare complication of DBS procedures, presenting from few days to months after surgery. Symptoms can be mild and not-specific, and the condition is self-limiting. The diagnosis of IDE is made after exclusion of vascular events or infections. The pathophysiology is still unexplained. The recognition of this complication can help avoiding unnecessary surgical procedures (system explantation) and antibiotic treatment.
(Copyright © 2016 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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