Neutrophil gelatinase-associated lipocalin as an early predictor of delayed graft function.
| Autor: | Nieto-Ríos JF; Grupo de Nefrología y Trasplante Renal, Hospital Pablo Tobón Uribe, Universidad de Antioquia, Medellín, Colombia. johnfredynieto@gmail.com., Serna-Higuita LM, Ocampo-Kohn C, Aristizábal-Alzate A, Vélez-Echeverry C, Vanegas-Ruiz JJ, Bedoya AM, Lopera SL, Rojano-Held N, Giraldo ND, Zuluaga-Valencia GA |
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| Jazyk: | angličtina |
| Zdroj: | Biomedica : revista del Instituto Nacional de Salud [Biomedica] 2016 Jun 03; Vol. 36 (2), pp. 213-9. Date of Electronic Publication: 2016 Jun 03. |
| DOI: | 10.7705/biomedica.v36i2.2703 |
| Abstrakt: | Introduction: Delayed graft function occurs in about 20 to 50 percent of kidney transplants. Objective: To describe the behavior of urinary neutrophil gelatinase-associated lipocalin (NGALu) in deceased-donor renal transplant recipients and to compare this indicator with the percentage of creatinine decrease (PdC) for the early detection of delayed graft function. Materials and Methods: NGALu levels were evaluated in a prospective cohort in the first, 12th, 24th and 48th hours after kidney transplant, and compared with the daily PdC until day 5. Results: We included 79 patients in the study. Delayed graft function occurred in 13 patients (16.5%), and five patients (6.3%) required dialysis in the first week. NGALu levels at all cut-off points were higher in patients with delayed graft function (p=0.526, p=0.049, p=0.032, and p=0.001). NGALu levels above 120 ng/ml at 48 hours predicted delayed graft function with a sensitivity of 75% and a specificity of 71%. A PdC of 59.5% best discriminated the delayed graft function, with a sensitivity of 92% and a specificity of 83% at 48 hours. Using logistic regression for the adjusted delayed graft function, the only significant values to predict it were those of PdC. Conclusions: NGALu levels measured at 48 hours after renal transplantation predicted delayed graft function, including the need for dialysis; however, this marker was not superior to the PdC for early detection. |
| Databáze: | MEDLINE |
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