The role of aquaporin-5 in cancer cell migration: A potential active participant.

Autor: Jensen HH; Department of Clinical Medicine, Aarhus University, 8000 Aarhus, Denmark; Department of Molecular Biology and Genetics, Aarhus University, 8000 Aarhus, Denmark., Login FH; Department of Clinical Medicine, Aarhus University, 8000 Aarhus, Denmark., Koffman JS; Interdisciplinary Nanoscience Center (iNANO), Aarhus University, 8000 Aarhus, Denmark., Kwon TH; Department of Biochemistry and Cell Biology, School of Medicine, Kyungpook National University, Taegu 41944, Republic of Korea., Nejsum LN; Department of Clinical Medicine, Aarhus University, 8000 Aarhus, Denmark. Electronic address: nejsum@clin.au.dk.
Jazyk: angličtina
Zdroj: The international journal of biochemistry & cell biology [Int J Biochem Cell Biol] 2016 Oct; Vol. 79, pp. 271-276. Date of Electronic Publication: 2016 Sep 05.
DOI: 10.1016/j.biocel.2016.09.005
Abstrakt: Emerging data identifies the water channel aquaporin-5 as a major player in multiple cancers. Over-expression of aquaporin-5 has been associated with increased metastasis and poor prognosis, suggesting that aquaporin-5 may enhance cancer cell migration. This review aims to highlight the current knowledge and hypothesis regarding downstream signaling partners of aquaporin-5 in relation to cancer cell migration. The molecular mechanisms that link aquaporin-5 to cell migration are not completely understood. Aquaporin-5 may promote cell movement by increasing water uptake into the front of the cell allowing local swelling. Aquaporin-5 may also activate extracellular-regulated kinases, increasing proliferation and potentially stimulating the migration machinery. Thus, further studies are warranted to identify the underlying mechanisms and signaling pathways. This will reveal whether aquaporin-5 and downstream effectors could be targets for developing new cancer therapeutics.
(Copyright © 2016 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: