[Impact of СD8/FoxP3 T lymphocyte ratio in the peritumoral area of primary cutaneous melanoma on the prognosis of the disease].
| Autor: | Bozhchenko YA; N.N. Blokhin Russian Cancer Research Center, Ministry of Health of the Russian Federation, Moscow, Russia., Vishnevskaya YV; N.N. Blokhin Russian Cancer Research Center, Ministry of Health of the Russian Federation, Moscow, Russia., Pokataev IA; N.N. Blokhin Russian Cancer Research Center, Ministry of Health of the Russian Federation, Moscow, Russia., Kokosadze NV; N.N. Blokhin Russian Cancer Research Center, Ministry of Health of the Russian Federation, Moscow, Russia., Demidov LV; N.N. Blokhin Russian Cancer Research Center, Ministry of Health of the Russian Federation, Moscow, Russia. |
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| Jazyk: | ruština |
| Zdroj: | Arkhiv patologii [Arkh Patol] 2016 Jul-Aug; Vol. 78 (4), pp. 27-31. |
| DOI: | 10.17116/patol201678427-31 |
| Abstrakt: | Unlabelled: Cutaneous melanoma (CM) is a malignant tumor characterized by typical histological features, one of which is tumor-infiltrating lymphocytes (TIL) that reflect the state of local immunity and determines the course of the disease. Aim: to study a correlation of the ratio of CD8/Foxp3 T lymphocyte subpopulations infiltrating primary cutaneous melanoma (PCM) with the clinical and morphological factors and prognosis of the disease. Material and Methods: The CD8+ and FoxP3+ T-lymphocyte subpopulations infiltrating PCM were investigated in 180 cases by immunohistochemical staining with anti-CD8 and anti-FoxP3 antibodies. Results: The predominant type of TIL was CD8+ cytotoxic T lymphocytes (80.1 cells in the field of vision); FoxP3+ T lymphocytes averaged 34.9 cells in the field of vision. There was a statistically significant correlation of a high ratio of CD8/FoxP3 T cells with disease stage, ulceration and regression segments in PCM, a low disease progression rate, and higher 5-year overall and relapse-free survival. Conclusion: The findings may be used in researches and in the practical work of pathologists and clinicians. |
| Databáze: | MEDLINE |
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