The relationship of the oleic acid level and ECHDC3 mRNA expression with the extent of coronary lesion.

Autor: Duarte MK; Postgraduate Program of Nutrition, Federal University of Rio Grande do Norte, Natal, Brazil., de Araújo JN; Department of Clinical and Toxicological Analysis, Federal Universty of Rio Grande do Norte, Natal, Brazil. Avenue General Gustavo Cordeiro de Farias, S/N, Natal, Rio Grande do Norte, CEP: 59014-520, Brazil., Duarte VH; Department of Clinical and Toxicological Analysis, Federal Universty of Rio Grande do Norte, Natal, Brazil. Avenue General Gustavo Cordeiro de Farias, S/N, Natal, Rio Grande do Norte, CEP: 59014-520, Brazil., de Oliveira KM; Department of Clinical and Toxicological Analysis, Federal Universty of Rio Grande do Norte, Natal, Brazil. Avenue General Gustavo Cordeiro de Farias, S/N, Natal, Rio Grande do Norte, CEP: 59014-520, Brazil., de Oliveira JM; Hospital Universitário Onofre Lopes, Federal University of Rio Grande do Norte, Natal, Brazil., Carioca AA; Nutrition Department, School of Public Health, University of São Paulo, São Paulo, Brazil., Bortolin RH; Department of Clinical and Toxicological Analysis, Federal Universty of Rio Grande do Norte, Natal, Brazil. Avenue General Gustavo Cordeiro de Farias, S/N, Natal, Rio Grande do Norte, CEP: 59014-520, Brazil., Rezende AA; Department of Clinical and Toxicological Analysis, Federal Universty of Rio Grande do Norte, Natal, Brazil. Avenue General Gustavo Cordeiro de Farias, S/N, Natal, Rio Grande do Norte, CEP: 59014-520, Brazil., Hirata MH; Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil., Hirata RD; Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil., Waitzberg DL; Faculty of Medicine (LIM-35), University of São Paulo, São Paulo, Brazil., Lima SC; Department of Nutrition, Federal University of Rio Grande do Norte, Natal, Brazil., Luchessi AD; Department of Clinical and Toxicological Analysis, Federal Universty of Rio Grande do Norte, Natal, Brazil. Avenue General Gustavo Cordeiro de Farias, S/N, Natal, Rio Grande do Norte, CEP: 59014-520, Brazil., Silbiger VN; Department of Clinical and Toxicological Analysis, Federal Universty of Rio Grande do Norte, Natal, Brazil. Avenue General Gustavo Cordeiro de Farias, S/N, Natal, Rio Grande do Norte, CEP: 59014-520, Brazil. viviansilbiger@hotmail.com.
Jazyk: angličtina
Zdroj: Lipids in health and disease [Lipids Health Dis] 2016 Sep 01; Vol. 15, pp. 144. Date of Electronic Publication: 2016 Sep 01.
DOI: 10.1186/s12944-016-0312-6
Abstrakt: Background: The fatty acid profile is associated with the risk and progression of several diseases, probably via mechanisms including its influence on gene expression. We previously reported a correlation between ECHDC3 upregulation and the severity of acute coronary syndrome. Here, we assessed the relationship of serum fatty acid profile and ECHDC3 expression with the extent of coronary lesion.
Methods: Fifty-nine individuals aged 30 to 74 years and undergoing elective cinecoronariography for the first time were enrolled in the present study. The extent of coronary lesion was assessed by the Friesinger index and patients were classified as without lesion (n = 18), low lesion (n = 17), intermediate lesion (n = 17) and major lesion (n = 7). Serum biochemistry, fatty acid concentration, and ECHDC3 mRNA expression in blood were evaluated.
Results: Elevated serum levels of oleic acid and total monounsaturated fatty acids were observed in patients with low and intermediate lesion, when compared to patients without lesion (p < 0.05). ECHDC3 mRNA expression was 1.2 fold higher in patients with low lesion than in patients without lesion (p = 0.020), and 1.8 fold lower in patients with major lesion patients than in patients with low lesion (p = 0.023).
Conclusion: Increased levels of monounsaturated fatty acids, especially oleic acid, and ECHDC3 upregulation in patients with coronary artery lesion suggests that these are independent factors associated with the initial progression of cardiovascular disease.
Databáze: MEDLINE
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