Citric acid crosslinked cyclodextrin/hydroxypropylmethylcellulose hydrogel films for hydrophobic drug delivery.

Autor: Ghorpade VS; Department of Pharmaceutics, YSPM's Yashoda Technical Campus, Wadhephata, Satara, 415011 Maharashtra, India. Electronic address: vsg.bpharm@yes.edu.in., Yadav AV; Department of Pharmaceutics, Gourishankar Institute of Pharmaceutical Education and Research, Limb, Satara, Maharashtra, India., Dias RJ; Department of Pharmaceutics, YSPM's Yashoda Technical Campus, Wadhephata, Satara, 415011 Maharashtra, India.
Jazyk: angličtina
Zdroj: International journal of biological macromolecules [Int J Biol Macromol] 2016 Dec; Vol. 93 (Pt A), pp. 75-86. Date of Electronic Publication: 2016 Aug 28.
DOI: 10.1016/j.ijbiomac.2016.08.072
Abstrakt: The present communication deals with preparation of β-cyclodextrin (βCD) grafted hydroxypropylmethylcellulose (HPMC) hydrogel films using citric acid as crosslinking agent with the aim of improving the loading and achieving controlled release of hydrophobic weak base (ketoconazole). The hydrogel films were characterized by attenuated total reflectance-fourier transform infrared (ATR-FTIR) spectroscopy, solid state 13 C-nuclear magnetic resonance ( 13 C NMR) spectroscopy, thermal analysis and scanning electron microscopy (SEM). The films were evaluated for βCD content, carboxyl content, swelling ratio, drug loading, drug release and hemolytic assay. ATR-FTIR spectra indicated crosslinking via ester formation whereas 13 C NMR, thermal analysis and SEM confirmed βCD grafting. The βCD grafted hydrogel films with high carboxyl content showed maximum swelling and high drug loading. The presence of grafted βCD helped to retard the release of ketoconazole from the hydrogel films. The hemolytic assay suggested the biocompatible nature of the hydrogel films. Altogether, βCD grafted HPMC hydrogel films were found to be suitable for delivery of poorly soluble weak bases.
(Copyright © 2016 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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