DEAH-RHA helicase•Znf cofactor systems in kinetoplastid RNA editing and evolutionarily distant RNA processes.
| Autor: | Cruz-Reyes J; Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX 77843, USA., Mooers BH; Department of Biochemistry & Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA., Abu-Adas Z; Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX 77843, USA., Kumar V; Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX 77843, USA., Gulati S; Department of Biochemistry & Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA. |
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| Jazyk: | angličtina |
| Zdroj: | RNA & disease (Houston, Tex.) [RNA Dis] 2016; Vol. 3 (2). Date of Electronic Publication: 2016 Jun 06. |
| DOI: | 10.14800/rd.1336 |
| Abstrakt: | Multi-zinc finger proteins are an emerging class of cofactors in DEAH-RHA RNA helicases across highly divergent eukaryotic lineages. DEAH-RHA helicase•zinc finger cofactor partnerships predate the split of kinetoplastid protozoa, which include several human pathogens, from other eukaryotic lineages 100-400 Ma. Despite a long evolutionary history, the prototypical DEAH-RHA domains remain highly conserved. This short review focuses on a recently identified DEAH-RHA helicase•zinc finger cofactor system in kinetoplastid RNA editing, and its potential functional parallels with analogous systems in embryogenesis control in nematodes and antivirus protection in humans. |
| Databáze: | MEDLINE |
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