Association of Weight and Body Composition on Cardiac Structure and Function in the ARIC Study (Atherosclerosis Risk in Communities).

Autor:	Bello NA; From the Division of Cardiology, Department of Medicine, Columbia University Medical Center, New York, NY (N.A.B.); Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (S.C., B.C., A.M.S., G.Q.R., A.B.S.S., S.D.S.); Department of Medicine, Johns Hopkins University, Baltimore, MD (C.E.N., J.C.); Department of Medicine, Vanderbilt Heart and Vascular Institute, Vanderbilt University Medical Center, Nashville, TN (D.G.); Pharmacy Practice Division, University of Wisconsin School of Pharmacy, Madison (O.V.); Section of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, TX (D.A.); Division of Epidemiology and Community Health, University of Minnesota, Minneapolis (A.R.F.); Department of Medicine, University of Mississippi Medical Center, Jackson (K.R.B.); and Cardiovascular Medicine Section, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC (D.W.K.)., Cheng S; From the Division of Cardiology, Department of Medicine, Columbia University Medical Center, New York, NY (N.A.B.); Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (S.C., B.C., A.M.S., G.Q.R., A.B.S.S., S.D.S.); Department of Medicine, Johns Hopkins University, Baltimore, MD (C.E.N., J.C.); Department of Medicine, Vanderbilt Heart and Vascular Institute, Vanderbilt University Medical Center, Nashville, TN (D.G.); Pharmacy Practice Division, University of Wisconsin School of Pharmacy, Madison (O.V.); Section of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, TX (D.A.); Division of Epidemiology and Community Health, University of Minnesota, Minneapolis (A.R.F.); Department of Medicine, University of Mississippi Medical Center, Jackson (K.R.B.); and Cardiovascular Medicine Section, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC (D.W.K.)., Claggett B; From the Division of Cardiology, Department of Medicine, Columbia University Medical Center, New York, NY (N.A.B.); Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (S.C., B.C., A.M.S., G.Q.R., A.B.S.S., S.D.S.); Department of Medicine, Johns Hopkins University, Baltimore, MD (C.E.N., J.C.); Department of Medicine, Vanderbilt Heart and Vascular Institute, Vanderbilt University Medical Center, Nashville, TN (D.G.); Pharmacy Practice Division, University of Wisconsin School of Pharmacy, Madison (O.V.); Section of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, TX (D.A.); Division of Epidemiology and Community Health, University of Minnesota, Minneapolis (A.R.F.); Department of Medicine, University of Mississippi Medical Center, Jackson (K.R.B.); and Cardiovascular Medicine Section, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC (D.W.K.)., Shah AM; From the Division of Cardiology, Department of Medicine, Columbia University Medical Center, New York, NY (N.A.B.); Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (S.C., B.C., A.M.S., G.Q.R., A.B.S.S., S.D.S.); Department of Medicine, Johns Hopkins University, Baltimore, MD (C.E.N., J.C.); Department of Medicine, Vanderbilt Heart and Vascular Institute, Vanderbilt University Medical Center, Nashville, TN (D.G.); Pharmacy Practice Division, University of Wisconsin School of Pharmacy, Madison (O.V.); Section of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, TX (D.A.); Division of Epidemiology and Community Health, University of Minnesota, Minneapolis (A.R.F.); Department of Medicine, University of Mississippi Medical Center, Jackson (K.R.B.); and Cardiovascular Medicine Section, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC (D.W.K.)., Ndumele CE; From the Division of Cardiology, Department of Medicine, Columbia University Medical Center, New York, NY (N.A.B.); Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (S.C., B.C., A.M.S., G.Q.R., A.B.S.S., S.D.S.); Department of Medicine, Johns Hopkins University, Baltimore, MD (C.E.N., J.C.); Department of Medicine, Vanderbilt Heart and Vascular Institute, Vanderbilt University Medical Center, Nashville, TN (D.G.); Pharmacy Practice Division, University of Wisconsin School of Pharmacy, Madison (O.V.); Section of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, TX (D.A.); Division of Epidemiology and Community Health, University of Minnesota, Minneapolis (A.R.F.); Department of Medicine, University of Mississippi Medical Center, Jackson (K.R.B.); and Cardiovascular Medicine Section, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC (D.W.K.)., Roca GQ; From the Division of Cardiology, Department of Medicine, Columbia University Medical Center, New York, NY (N.A.B.); Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (S.C., B.C., A.M.S., G.Q.R., A.B.S.S., S.D.S.); Department of Medicine, Johns Hopkins University, Baltimore, MD (C.E.N., J.C.); Department of Medicine, Vanderbilt Heart and Vascular Institute, Vanderbilt University Medical Center, Nashville, TN (D.G.); Pharmacy Practice Division, University of Wisconsin School of Pharmacy, Madison (O.V.); Section of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, TX (D.A.); Division of Epidemiology and Community Health, University of Minnesota, Minneapolis (A.R.F.); Department of Medicine, University of Mississippi Medical Center, Jackson (K.R.B.); and Cardiovascular Medicine Section, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC (D.W.K.)., Santos AB; From the Division of Cardiology, Department of Medicine, Columbia University Medical Center, New York, NY (N.A.B.); Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (S.C., B.C., A.M.S., G.Q.R., A.B.S.S., S.D.S.); Department of Medicine, Johns Hopkins University, Baltimore, MD (C.E.N., J.C.); Department of Medicine, Vanderbilt Heart and Vascular Institute, Vanderbilt University Medical Center, Nashville, TN (D.G.); Pharmacy Practice Division, University of Wisconsin School of Pharmacy, Madison (O.V.); Section of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, TX (D.A.); Division of Epidemiology and Community Health, University of Minnesota, Minneapolis (A.R.F.); Department of Medicine, University of Mississippi Medical Center, Jackson (K.R.B.); and Cardiovascular Medicine Section, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC (D.W.K.)., Gupta D; From the Division of Cardiology, Department of Medicine, Columbia University Medical Center, New York, NY (N.A.B.); Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (S.C., B.C., A.M.S., G.Q.R., A.B.S.S., S.D.S.); Department of Medicine, Johns Hopkins University, Baltimore, MD (C.E.N., J.C.); Department of Medicine, Vanderbilt Heart and Vascular Institute, Vanderbilt University Medical Center, Nashville, TN (D.G.); Pharmacy Practice Division, University of Wisconsin School of Pharmacy, Madison (O.V.); Section of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, TX (D.A.); Division of Epidemiology and Community Health, University of Minnesota, Minneapolis (A.R.F.); Department of Medicine, University of Mississippi Medical Center, Jackson (K.R.B.); and Cardiovascular Medicine Section, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC (D.W.K.)., Vardeny O; From the Division of Cardiology, Department of Medicine, Columbia University Medical Center, New York, NY (N.A.B.); Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (S.C., B.C., A.M.S., G.Q.R., A.B.S.S., S.D.S.); Department of Medicine, Johns Hopkins University, Baltimore, MD (C.E.N., J.C.); Department of Medicine, Vanderbilt Heart and Vascular Institute, Vanderbilt University Medical Center, Nashville, TN (D.G.); Pharmacy Practice Division, University of Wisconsin School of Pharmacy, Madison (O.V.); Section of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, TX (D.A.); Division of Epidemiology and Community Health, University of Minnesota, Minneapolis (A.R.F.); Department of Medicine, University of Mississippi Medical Center, Jackson (K.R.B.); and Cardiovascular Medicine Section, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC (D.W.K.)., Aguilar D; From the Division of Cardiology, Department of Medicine, Columbia University Medical Center, New York, NY (N.A.B.); Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (S.C., B.C., A.M.S., G.Q.R., A.B.S.S., S.D.S.); Department of Medicine, Johns Hopkins University, Baltimore, MD (C.E.N., J.C.); Department of Medicine, Vanderbilt Heart and Vascular Institute, Vanderbilt University Medical Center, Nashville, TN (D.G.); Pharmacy Practice Division, University of Wisconsin School of Pharmacy, Madison (O.V.); Section of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, TX (D.A.); Division of Epidemiology and Community Health, University of Minnesota, Minneapolis (A.R.F.); Department of Medicine, University of Mississippi Medical Center, Jackson (K.R.B.); and Cardiovascular Medicine Section, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC (D.W.K.)., Folsom AR; From the Division of Cardiology, Department of Medicine, Columbia University Medical Center, New York, NY (N.A.B.); Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (S.C., B.C., A.M.S., G.Q.R., A.B.S.S., S.D.S.); Department of Medicine, Johns Hopkins University, Baltimore, MD (C.E.N., J.C.); Department of Medicine, Vanderbilt Heart and Vascular Institute, Vanderbilt University Medical Center, Nashville, TN (D.G.); Pharmacy Practice Division, University of Wisconsin School of Pharmacy, Madison (O.V.); Section of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, TX (D.A.); Division of Epidemiology and Community Health, University of Minnesota, Minneapolis (A.R.F.); Department of Medicine, University of Mississippi Medical Center, Jackson (K.R.B.); and Cardiovascular Medicine Section, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC (D.W.K.)., Butler KR; From the Division of Cardiology, Department of Medicine, Columbia University Medical Center, New York, NY (N.A.B.); Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (S.C., B.C., A.M.S., G.Q.R., A.B.S.S., S.D.S.); Department of Medicine, Johns Hopkins University, Baltimore, MD (C.E.N., J.C.); Department of Medicine, Vanderbilt Heart and Vascular Institute, Vanderbilt University Medical Center, Nashville, TN (D.G.); Pharmacy Practice Division, University of Wisconsin School of Pharmacy, Madison (O.V.); Section of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, TX (D.A.); Division of Epidemiology and Community Health, University of Minnesota, Minneapolis (A.R.F.); Department of Medicine, University of Mississippi Medical Center, Jackson (K.R.B.); and Cardiovascular Medicine Section, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC (D.W.K.)., Kitzman DW; From the Division of Cardiology, Department of Medicine, Columbia University Medical Center, New York, NY (N.A.B.); Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (S.C., B.C., A.M.S., G.Q.R., A.B.S.S., S.D.S.); Department of Medicine, Johns Hopkins University, Baltimore, MD (C.E.N., J.C.); Department of Medicine, Vanderbilt Heart and Vascular Institute, Vanderbilt University Medical Center, Nashville, TN (D.G.); Pharmacy Practice Division, University of Wisconsin School of Pharmacy, Madison (O.V.); Section of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, TX (D.A.); Division of Epidemiology and Community Health, University of Minnesota, Minneapolis (A.R.F.); Department of Medicine, University of Mississippi Medical Center, Jackson (K.R.B.); and Cardiovascular Medicine Section, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC (D.W.K.)., Coresh J; From the Division of Cardiology, Department of Medicine, Columbia University Medical Center, New York, NY (N.A.B.); Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (S.C., B.C., A.M.S., G.Q.R., A.B.S.S., S.D.S.); Department of Medicine, Johns Hopkins University, Baltimore, MD (C.E.N., J.C.); Department of Medicine, Vanderbilt Heart and Vascular Institute, Vanderbilt University Medical Center, Nashville, TN (D.G.); Pharmacy Practice Division, University of Wisconsin School of Pharmacy, Madison (O.V.); Section of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, TX (D.A.); Division of Epidemiology and Community Health, University of Minnesota, Minneapolis (A.R.F.); Department of Medicine, University of Mississippi Medical Center, Jackson (K.R.B.); and Cardiovascular Medicine Section, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC (D.W.K.)., Solomon SD; From the Division of Cardiology, Department of Medicine, Columbia University Medical Center, New York, NY (N.A.B.); Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (S.C., B.C., A.M.S., G.Q.R., A.B.S.S., S.D.S.); Department of Medicine, Johns Hopkins University, Baltimore, MD (C.E.N., J.C.); Department of Medicine, Vanderbilt Heart and Vascular Institute, Vanderbilt University Medical Center, Nashville, TN (D.G.); Pharmacy Practice Division, University of Wisconsin School of Pharmacy, Madison (O.V.); Section of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, TX (D.A.); Division of Epidemiology and Community Health, University of Minnesota, Minneapolis (A.R.F.); Department of Medicine, University of Mississippi Medical Center, Jackson (K.R.B.); and Cardiovascular Medicine Section, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC (D.W.K.). ssolomon@rics.bwh.harvard.edu.
Jazyk:	angličtina
Zdroj:	Circulation. Heart failure [Circ Heart Fail] 2016 Aug; Vol. 9 (8).
DOI:	10.1161/CIRCHEARTFAILURE.115.002978
Abstrakt:	Background: Obesity increases cardiovascular risk. However, the extent to which various measures of body composition are associated with abnormalities in cardiac structure and function, independent of comorbidities commonly affecting obese individuals, is not clear. This study sought to examine the relationship between body mass index, waist circumference, and percent body fat with conventional and advanced measures of cardiac structure and function. Methods and Results: We studied 4343 participants of the ARIC study (Atherosclerosis Risk in Communities) who were aged 69 to 82 years, free of coronary heart disease and heart failure, and underwent comprehensive echocardiography. Increasing body mass index, waist circumference, and body fat were associated with greater left ventricular (LV) mass and left atrial volume indexed to height(2.7) in both men and women (P<0.001). In women, all 3 measures were associated with abnormal LV geometry, and increasing waist circumference and body fat were associated with worse global longitudinal strain, a measure of LV systolic function. In both sexes, increasing body mass index was associated with greater right ventricular end-diastolic area and worse right ventricular fractional area change (P≤0.001). We observed similar associations for both waist circumference and percent body fat. Conclusions: In a large, biracial cohort of older adults free of clinically overt coronary heart disease or heart failure, obesity was associated with subclinical abnormalities in cardiac structure in both men and women and with adverse LV remodeling and impaired LV systolic function in women. These data highlight the association of obesity and subclinical abnormalities of cardiac structure and function, particularly in women. (© 2016 American Heart Association, Inc.)
Databáze:	MEDLINE
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