Predictive cytokine biomarkers of clinical response to glatiramer acetate therapy in multiple sclerosis.

Autor: Valenzuela RM; Rutgers-Robert Wood Johnson Medical School, Piscataway, NJ 08854, United States. Electronic address: valenzru@gmail.com., Kaufman M; Carolina Medical Center, Multiple Sclerosis Center, Charlotte, North Carolina, 28207, United States. Electronic address: gpmonk1@gmail.com., Balashov KE; Rutgers-Robert Wood Johnson Medical School, Piscataway, NJ 08854, United States. Electronic address: kbalashov@yahoo.com., Ito K; Rutgers-Robert Wood Johnson Medical School, Piscataway, NJ 08854, United States. Electronic address: itoko@rwjms.rutgers.edu., Buyske S; Rutgers University, Department of Statistics and Biostatistics, Piscataway, NJ 08854, United States. Electronic address: buyske@stat.rutgers.edu., Dhib-Jalbut S; Rutgers-Robert Wood Johnson Medical School, Piscataway, NJ 08854, United States. Electronic address: jalbutsu@rutgers.edu.
Jazyk: angličtina
Zdroj: Journal of neuroimmunology [J Neuroimmunol] 2016 Nov 15; Vol. 300, pp. 59-65. Date of Electronic Publication: 2016 Jul 02.
DOI: 10.1016/j.jneuroim.2016.06.005
Abstrakt: A prospective study of 62 patients with relapsing-remitting multiple sclerosis (RRMS) treated with Glatiramer acetate (GA) was conducted to evaluate the value of baseline and treatment-modulated cytokines in predicting the clinical response to the drug after 2years of therapy. There were 32 responders and 30 non-responders. GA upregulated Th2/regulatory cytokines and inhibited Th1 cytokines in sera or PBMC supernatants 3 and 6months into treatment. We found two prognostic models with clinical utility. A model based on IL-18 at baseline, the change in TNFa from baseline to 3months, the change in IL-4 from baseline to 6months, and the change in the log of the ratio of TNFa/IL-4 from baseline to 6months had an area under the curve (AUC) of 0.80. A high IL-18 level at baseline and a reduction of TNF-alpha over time are associated with a response to GA. Although the study identified predictive biomarkers of clinical response to GA, the results will need to be validated in other data sets.
(Copyright © 2016 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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