Associations between nasopharyngeal carriage of Group B Streptococcus and other respiratory pathogens during early infancy.

Autor: Foster-Nyarko E; Vaccines and Immunity Theme, Medical Research Council Unit, Banjul, The Gambia., Kwambana B; Vaccines and Immunity Theme, Medical Research Council Unit, Banjul, The Gambia., Aderonke O; Vaccines and Immunity Theme, Medical Research Council Unit, Banjul, The Gambia., Ceesay F; Vaccines and Immunity Theme, Medical Research Council Unit, Banjul, The Gambia., Jarju S; Vaccines and Immunity Theme, Medical Research Council Unit, Banjul, The Gambia., Bojang A; Vaccines and Immunity Theme, Medical Research Council Unit, Banjul, The Gambia., McLellan J; Vaccines and Immunity Theme, Medical Research Council Unit, Banjul, The Gambia., Jafali J; Vaccines and Immunity Theme, Medical Research Council Unit, Banjul, The Gambia., Kampmann B; Vaccines and Immunity Theme, Medical Research Council Unit, Banjul, The Gambia., Ota MO; Vaccines and Immunity Theme, Medical Research Council Unit, Banjul, The Gambia.; Current Address: WHO Regional Office for Africa, Brazzaville, Congo., Adetifa I; Disease Control and Elimination Theme, Medical Research Council Unit, Banjul, The Gambia.; Current Address: Infectious Diseases Epidemiology, London School of Hygiene & Tropical Medicine, London, UK., Antonio M; Vaccines and Immunity Theme, Medical Research Council Unit, Banjul, The Gambia. mantonio@mrc.gm.; Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK. mantonio@mrc.gm.; Microbiology and Infection Unit, Warwick Medical School, University of Warwick, Coventry, UK. mantonio@mrc.gm.
Jazyk: angličtina
Zdroj: BMC microbiology [BMC Microbiol] 2016 May 27; Vol. 16, pp. 97. Date of Electronic Publication: 2016 May 27.
DOI: 10.1186/s12866-016-0714-7
Abstrakt: Background: In West Africa, the carriage of Group B Streptococcus (GBS), among infants is poorly characterised. We investigated co-carriage of GBS with other respiratory pathogens in the infants' nasopharynx in The Gambia.
Methods: We assessed the carriage, serotypes and antibiotic susceptibility of Beta-haemolytic Streptococci (BHS) groups A-G; along with the carriage of Streptococcus pneumoniae; Haemophilus influenzae; Staphylococcus aureus and Moraxella catarrhalis in 1200 two-month old infants.
Results: The BHS prevalence was 20.0 % and GBS dominated (13.8 %), particularly serotypes V and II; serotype V being negatively associated with H. Influenzae carriage (OR 0.41 [95 % CI: 0.18-0.93], p = 0.033). Although co-colonization of GBS and other BHS was not seen, colonization with GBS was positively associated with S. aureus (OR 1.89 [95 % CI: 1.33-2.69], P < 0.001) and negatively associated with S. pneumoniae (OR 0.47 [95 % CI: 0.33-0.67], p < 0.001) and M. catarrhalis (OR 0.61 [95 % CI: 0.40-0.92], p = 0.017). ≥ 89 % of GBS isolates were susceptible to most antibiotics tested, except for tetracycline resistance, which was 89 %.
Conclusion: This study provides baseline data on the carriage of GBS in two month old infants from West Africa. The dominant serotypes of GBS in this setting are serotypes V and II. This may be important for future GBS vaccine development for the West African sub-region.
Databáze: MEDLINE
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