Efficacy, safety and effectiveness of ondansetron compared to other serotonin-3 receptor antagonists (5-HT3RAs) used to control chemotherapy-induced nausea and vomiting: systematic review and meta-analysis.

Autor:	Simino GP; a Basic Nursing Departament, Nursing School , Federal University of Minas Gerais , Belo Horizonte , Brazil., Marra LP; b Social Pharmacy Departament , Faculty of Pharmacy, Federal University of Minas Gerais , Belo Horizonte , Brazil., Andrade EI; c Preventive and Social Medicine, Medical School , Federal University of Minas Gerais , Belo Horizonte , Brazil., Acúrcio Fde A; b Social Pharmacy Departament , Faculty of Pharmacy, Federal University of Minas Gerais , Belo Horizonte , Brazil., Reis IA; d Statistics Department, Exact sciencesInstitute , Federal University of Minas Gerais , Belo Horizonte , Brazil., De Araújo VE; e Department of Dentistry , Pontifical Catholic University of Minas Gerais , Belo Horizonte , Brazil., Cherchiglia ML; f Preventive and Social Medicine. Medical School . Federal University of Minas Gerais , Belo Horizonte , Brazil.
Jazyk:	angličtina
Zdroj:	Expert review of clinical pharmacology [Expert Rev Clin Pharmacol] 2016 Sep; Vol. 9 (9), pp. 1183-94. Date of Electronic Publication: 2016 Jun 15.
DOI:	10.1080/17512433.2016.1190271
Abstrakt:	Introduction: Chemotherapy-induced nausea and vomiting are adverse effects responsible for worsening quality of life in cancer patients. To assess the efficacy, safety and effectiveness of serotonin receptor antagonist in cancer patients undergoing chemotherapy, comparing ondansetron with granisetron, dolasetron, tropisetron and palonosetron. Areas Covered: Systematic review and meta-analysis. The data were collected using CINAHL; CENTRAL; MEDLINE/PubMed; and LILACS databases; grey literature; and manual search. The methodological quality was assessed using the modified Jadad scale; Cochrane Collaboration's tool for assessing risk of bias in randomized clinical trials and the Newcastle-Ottawa Scale for observational studies. The search was completed in November, 2015. 26 studies were included in the meta-analysis. Ondansetron exhibited similar efficacy than granisetron and tropisetron, as well as greater efficacy than dolasetron for acute vomiting. Palonosetron exhibited greater efficacy than ondansetron for delayed nausea and acute and delayed vomiting. The comparison of granisetron with ondansetron in the cohort studies showed no difference. Expert commentary: In this review, palonosetron had increased efficiency compared with ondansetron, except in the subgroup analysis and acute nausea. Few cohort studies have been published addressing this topic.
Databáze:	MEDLINE
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