Genome-wide association study of periweaning failure-to-thrive syndrome (PFTS) in pigs.

Autor: Zanella R; Embrapa Swine and Poultry National Research Center, Concordia, SC, Brazil., Morés N; Embrapa Swine and Poultry National Research Center, Concordia, SC, Brazil., Morés MA; Embrapa Swine and Poultry National Research Center, Concordia, SC, Brazil., Peixoto JO; Embrapa Swine and Poultry National Research Center, Concordia, SC, Brazil., Zanella EL; R. Zanella's present address is College of Veterinary Medicine, University of Passo Fundo, Passo Fundo, RS, Brazil., Ciacci-Zanella JR; Embrapa Swine and Poultry National Research Center, Concordia, SC, Brazil., Ibelli AM; Embrapa Swine and Poultry National Research Center, Concordia, SC, Brazil., Gava D; Embrapa Swine and Poultry National Research Center, Concordia, SC, Brazil., Cantão ME; Embrapa Swine and Poultry National Research Center, Concordia, SC, Brazil., Ledur MC; Embrapa Swine and Poultry National Research Center, Concordia, SC, Brazil.
Jazyk: angličtina
Zdroj: The Veterinary record [Vet Rec] 2016 Jun 25; Vol. 178 (26), pp. 653. Date of Electronic Publication: 2016 May 09.
DOI: 10.1136/vr.103546
Abstrakt: Porcine periweaning-failure-to-thrive syndrome (PFTS) is a condition that affects newly weaned piglets. It is characterised by a progressive debilitation leading to death, in the absence of infectious, nutritional, management or environmental factors. In this study, we present the first report of PFTS in South America and the results of a genome-wide association study to identify the genetic markers associated with the appearance of this condition in a crossbred swine population. Four chromosomal regions were associated with PFTS predisposition, one located on SSCX, one on SSC8, and the two other regions on SSC14. Regions on SSC8 and SSC14 harbour important functional candidate genes involved in human depression and might have an important role in PFTS. Our findings contribute to the increasing knowledge about this syndrome, which has been investigated since 2007, and to the identification of the aetiology of this disease.
(British Veterinary Association.)
Databáze: MEDLINE
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