Translation, Cross-Cultural Adaptation, and Validation of the Lee Chronic Graft-versus-Host Disease Symptom Scale in a Brazilian Population.

Autor: Vasconcellos de Souza C; Bone Marrow Transplant Unit, University of Campinas, Campinas, Brazil., Vigorito AC; Bone Marrow Transplant Unit, University of Campinas, Campinas, Brazil., Miranda ECM; Bone Marrow Transplant Unit, University of Campinas, Campinas, Brazil., Garcia C Jr; Bone Marrow Transplant Unit, University of Campinas, Campinas, Brazil., Rensi Colturato VA; Bone Marrow Transplant Unit, Hospital Amaral Carvalho, Jaú, Brazil., Mauad MA; Bone Marrow Transplant Unit, Hospital Amaral Carvalho, Jaú, Brazil., Rodrigues Moreira MC; Bone Marrow Transplant Unit, National Institute of Cancer/Bone Marrow Transplant Center, Rio de Janeiro, Brazil., da Silva Bouzas LF; Bone Marrow Transplant Unit, National Institute of Cancer/Bone Marrow Transplant Center, Rio de Janeiro, Brazil., Lermontov S; Bone Marrow Transplant Unit, National Institute of Cancer/Bone Marrow Transplant Center, Rio de Janeiro, Brazil., Hamerschlak N; Bone Marrow Transplant Unit, Hospital Israelita Albert Einstein, São Paulo, Brazil., Rodrigues M; Bone Marrow Transplant Unit, Hospital Israelita Albert Einstein, São Paulo, Brazil., Carlos de Almeida Barros J; Bone Marrow Transplant Unit, Irmandade da Santa Casa de Misericórdia de São Paulo, São Paulo, Brazil., Chiattone R; Bone Marrow Transplant Unit, Irmandade da Santa Casa de Misericórdia de São Paulo, São Paulo, Brazil., Lee SJ; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington; Medical Oncology, University of Washington, Seattle, Washington., Flowers MED; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington; Medical Oncology, University of Washington, Seattle, Washington. Electronic address: mflowers@fhcrc.org.
Jazyk: angličtina
Zdroj: Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation [Biol Blood Marrow Transplant] 2016 Jul; Vol. 22 (7), pp. 1313-1318. Date of Electronic Publication: 2016 Apr 04.
DOI: 10.1016/j.bbmt.2016.03.013
Abstrakt: The Lee Chronic Graft-versus-Host Disease (GVHD) Symptom Scale is a patient-reported instrument developed and validated in English to measure the symptoms and functional impact of cGVHD. This tool has not yet been validated in a Latin American population, however. The Brazil-Seattle Chronic GVHD Consortium conducted a multicenter study at 5 Brazilian institutions to validate the Lee cGVHD Symptom Scale in adults with cGVHD. Study objectives included the translation and validation of the instrument in Brazilian Portuguese and evaluation of the correlation with other quality of life (QoL) tools, including the Medical Outcomes Study Short Form 36 (SF-36) and Functional Assessment of Chronic Illness Therapy with Bone Marrow Transplant subscale (FACT-BMT). Translation and validation were done according to the American Association of Orthopedic Surgeons Outcome Committee guidelines. Spearman's correlation coefficient was used to measure construct validity. Reliability was assessed using Cronbach's α and intraclass correlation coefficients. Between April 2011 and August 2012, 47 patients with cGVHD based on the 2005 National Institutes of Health criteria (29 males [62%], 18 females [38%]; median age, 48 years; range, 23 to 69 years) were enrolled in this study. The reliability of the Lee cGVHD Symptom Scale was adequate (Cronbach's α = 0.62 to 0.83). The correlations between similar domains of the Lee cGVHD Symptom Scale, SF-36, and FACT-BMT were moderate to high. Our data indicate that the Brazilian Portuguese version of the Lee cGVHD Symptom Scale is valid and reliable and can be used in clinical trials of cGVHD in Brazil.
(Copyright © 2016 American Society for Blood and Marrow Transplantation. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: