Dose reduction in half-time myocardial perfusion SPECT-CT with multifocal collimation.

Autor: Lyon MC; Division of Nuclear Medicine, Department of Radiology, Brigham and Women's Hospital, Boston, MA, USA. mlyon@invicro.com.; Department of Radiology, Harvard Medical School, Boston, MA, USA. mlyon@invicro.com.; inviCRO, 27 Drydock Ave, Boston, MA, 02210, USA. mlyon@invicro.com., Foster C; Division of Nuclear Medicine, Department of Radiology, Brigham and Women's Hospital, Boston, MA, USA., Ding X; Molecular Imaging, Siemens Medical Solutions USA, Inc., Hoffman Estates, IL, USA., Dorbala S; Division of Nuclear Medicine, Department of Radiology, Brigham and Women's Hospital, Boston, MA, USA.; Department of Radiology, Harvard Medical School, Boston, MA, USA., Spence D; Molecular Imaging, Siemens Medical Solutions USA, Inc., Hoffman Estates, IL, USA., Bhattacharya M; Molecular Imaging, Siemens Medical Solutions USA, Inc., Hoffman Estates, IL, USA., Vija AH; Molecular Imaging, Siemens Medical Solutions USA, Inc., Hoffman Estates, IL, USA., DiCarli MF; Division of Nuclear Medicine, Department of Radiology, Brigham and Women's Hospital, Boston, MA, USA.; Department of Radiology, Harvard Medical School, Boston, MA, USA., Moore SC; Division of Nuclear Medicine, Department of Radiology, Brigham and Women's Hospital, Boston, MA, USA.; Department of Radiology, Harvard Medical School, Boston, MA, USA.
Jazyk: angličtina
Zdroj: Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology [J Nucl Cardiol] 2016 Aug; Vol. 23 (4), pp. 657-67. Date of Electronic Publication: 2016 Mar 31.
DOI: 10.1007/s12350-016-0471-x
Abstrakt: Background: Recent technological advances in myocardial perfusion imaging may warrant the use of lower injected activity. We evaluated whether quantitative measures of stress myocardial perfusion defects using Tc-99m sestamibi and low-energy high-resolution (LEHR) collimators are equivalent to lower dose SPECT-CT with cardiac multifocal collimators and software (IQ·SPECT).
Methods: 93 patients underwent one-day rest-stress gated SPECT-CT. Following conventional rest imaging, 925-1100 MBq (25-30 mCi) of Tc-99m sestamibi was injected during stress testing. Stress SPECT-CT images were acquired two ways: with LEHR (13 minutes) and IQ·SPECT (7 minutes). Low-dose IQ·SPECT stress was simulated by subsampling the full-dose data to half-, quarter-, and eighth-count levels. Abnormalities were quantified using the total perfusion deficit (TPD) score and dose-specific databases.
Results: The mean ± SD of the differences between LEHR and IQ·SPECT TPD scores were -1.01 ± 5.36%, -0.10 ± 5.81%, 1.78 ± 4.81%, and 1.75 ± 6.05% at full, half, quarter, and eighth doses, respectively. Differences were statistically significant for quarter and eighth doses. Correlation between LEHR and IQ·SPECT was excellent at all doses (R ≥ 0.93). Bland-Altman plots demonstrated minimal bias.
Conclusions: With IQ·SPECT, quantitative stress SPECT-CT imaging is possible with half of the standard injected activity in half the time.
Databáze: MEDLINE
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