The Effect of anti-TNFα Induction Therapy on the Nutritional Status and Dietary Intake in Inflammatory Bowel Disease.

Autor: Csontos ÁA; 2nd Department of Medicine; Budapest, Hungary. csontosagnesanna@gmail.com., Molnár A; School of PhD Studies, Pathological Sciences, Health Science Research, Budapest, Hungary., Piri Z; 2nd Department of Medicine; Budapest, Hungary., Katona B; 2nd Department of Medicine; Budapest, Hungary., Dakó S; Faculty of Health Sciences Department of Dietetic and Nutrition Sciences, Semmelweis University, Budapest, Hungary., Pálfi E; Faculty of Health Sciences Department of Dietetic and Nutrition Sciences, Semmelweis University, Budapest, Hungary., Miheller P; 2nd Department of Medicine; Budapest, Hungary.
Jazyk: angličtina
Zdroj: Journal of gastrointestinal and liver diseases : JGLD [J Gastrointestin Liver Dis] 2016 Mar; Vol. 25 (1), pp. 49-56.
DOI: 10.15403/jgld.2014.1121.251.tnf
Abstrakt: Background and Aims: Patients suffering from inflammatory bowel disease (IBD) are at a high risk of malnutrition and retain an altered body composition. We hypothesized that anti-tumor necrosis factor (anti-TNF) alpha therapy may improve dietary intake and have a beneficial influence on body composition in these patients.
Methods: Our study involved 40 IBD outpatients (33 Crohn's disease, 7 ulcerative colitis); 24 of these received adalimumab (160/80/40EOW) and 16 were treated with infliximab (5 mg/kg at week 0, 2, 6, and subsequently every 8 weeks). Body composition was measured with bioelectrical impedance analysis, while dietary intake was recorded prior to initiating biologicals and 3 months afterwards. Body composition indexes: fat-free mass index [FFMI], body fat mass index [BFMI]) were calculated in kg/m2.
Results: Baseline BMI (kg/m2) and muscle parameters increased significantly at the end of the observational period (BMI: 23.81+/-7.19 vs. 24.52+/-7.34, p<0.001; FFMI: 17.64+/-3.00 vs. 18.14+/-3.08, p<0.001; at week 0 vs. 12, respectively). However, no significant changes were detected in the fat parameters (BFMI: 6.21+/-5.20 vs. 6.44+/-5.27, respectively). We found no significant difference between the effects of adalimumab vs. infliximab on body composition (deltaFFMI: 0.55+/-0.82 vs. 0.43+/-0.69; deltaBFMI: 0.23+/-0.85 vs. 0.21+/-1.01, respectively). No significant difference was observed in the extent of changes in parameters whether the patients were on corticosteroids (n=15) or not (n=25) at week 0 (deltaFFMI: 0.44+/-0.84 vs 0.59+/-0.72; deltaBFMI: 0.36+/-1.12 vs. 0.09+/-0.71, respectively).
Conclusion: Our findings suggest that muscle parameters improved during the anti-TNF induction therapy, while fat parameters did not change significantly. Thus, induction anti-TNF therapy might have a beneficial effect on body composition.
Databáze: MEDLINE
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