Immunoexpression of tumour necrosis factor-α, interleukin-1α and interleukin-10 on odontogenic cysts and tumours.

Autor: Sá MC; Faculty of Dentistry, Department of Oral Pathology, Federal University of Rio Grande do Norte, Natal, Brazil., de Matos FR; Department of Dentistry of Lagarto, Federal University of Sergipe, Lagarto, Brazil., Conceição TS; Faculty of Dentistry, Department of Oral Pathology, Federal University of Rio Grande do Norte, Natal, Brazil., Leitão AC; Department of Oral Pathology, Faculty of Dentistry, Federal University of Bahia, Salvador, Brazil., Freitas RA; Faculty of Dentistry, Department of Oral Pathology, Federal University of Rio Grande do Norte, Natal, Brazil.
Jazyk: angličtina
Zdroj: International endodontic journal [Int Endod J] 2017 May; Vol. 50 (5), pp. 437-445. Date of Electronic Publication: 2016 Apr 16.
DOI: 10.1111/iej.12640
Abstrakt: Aim: To analyse the immunoreactivity of IL-1α, TNF-α and IL-10 in odontogenic cysts and tumours and to investigate possible associations with established biological behaviours of these different lesions.
Methodology: Immunohistochemical expression of anti-IL-1α, anti-TNF-α and anti-IL-10 antibodies was assessed on epithelium and mesenchyme of 20 radicular cysts (RCs), 20 residual cysts (RECs), 20 dentigerous cysts (DCs), 18 solid ameloblastomas (SAs), 20 keratocystic odontogenic tumours (KCOTs) and 15 dental follicles (DFs). Comparative analysis of data was performed using the nonparametric Wilcoxon signed-rank test and Kruskal-Wallis's test.
Results: Significantly greater expression of IL-1α in the epithelium was noted in RC, KCOT and SA (P = 0.01), whilst IL-10 and TNF-α was in the epithelium of RC, DC and KCOT (P < 0.01). In the mesenchyme, significantly greater immunopositivity was observed for IL-1α, IL-10 and TNF-α in KCOT, DC and RC (P < 0.01). In epithelial and mesenchymal tissues, there were a significant number of cases of RC and DC with IL-1α < IL-10 ratio (P < 0.01), whilst SA and KCOT showed IL-1α > IL-10 (P < 0.01). There was a significantly greater percentage of DF, DC and KCOT with TNF-α > IL10 ratio (P < 0.01).
Conclusion: These results suggest involvement of the proteins in the pathogenesis of odontogenic cysts and tumours, with emphasis on the highest immunoreactivity of osteolysis stimulating factors in tumours with aggressive biological behaviour, such as SA and KCOT.
(© 2016 International Endodontic Journal. Published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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