Anti-tubercular therapy for intraocular tuberculosis: A systematic review and meta-analysis.

Autor: Kee AR; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Gonzalez-Lopez JJ; Tennent Institute of Ophthalmology, NHS Greater Glasgow and Clyde, Glasgow, UK. Electronic address: juliojose.gonzalez@live.com., Al-Hity A; Tennent Institute of Ophthalmology, NHS Greater Glasgow and Clyde, Glasgow, UK., Gupta B; Royal Berkshire Hospitals NHS Foundation Trust, Reading, UK; Moorfields Eye Hospital, NHS Foundation Trust, London, UK., Lee CS; University of Washington, Seattle, Washington, USA., Gunasekeran DV; National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore, Singapore., Jayabalan N; School of Materials Science & Engineering, Nanyang Technological University, Singapore, Singapore., Grant R; Kingston and St George's University of London, Kingston, UK., Kon OM; St Mary's Hospital, Imperial College Healthcare NHS Trust, London, UK., Gupta V; Advance Eye Centre, Postgraduate Institute of Medical Education & Research, Chandigarh, India., Westcott M; Moorfields Eye Hospital, NHS Foundation Trust, London, UK., Pavesio C; Moorfields Eye Hospital, NHS Foundation Trust, London, UK., Agrawal R; National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore, Singapore; School of Materials Science & Engineering, Nanyang Technological University, Singapore, Singapore; Moorfields Eye Hospital, NHS Foundation Trust, London, UK. Electronic address: rupesh_agrawal@ttsh.com.sg.
Jazyk: angličtina
Zdroj: Survey of ophthalmology [Surv Ophthalmol] 2016 Sep-Oct; Vol. 61 (5), pp. 628-53. Date of Electronic Publication: 2016 Mar 10.
DOI: 10.1016/j.survophthal.2016.03.001
Abstrakt: Intraocular tuberculosis remains a diagnostic and management conundrum for both ophthalmologists and pulmonologists. We analyze the efficacy and safety of anti-tubercular therapy (ATT) in patients with intraocular tuberculosis and factors associated with favorable outcome. Twenty-eight studies are included in this review, with a total of 1,917 patients. Nonrecurrence of inflammation was observed in pooled estimate of 84% of ATT-treated patients (95% CI 79-89). There was minimal difference in the outcome between patients treated with ATT alone (85% successful outcome; 95% CI 25-100) and those with concomitant systemic corticosteroid (82%; 95% CI 73-90). The use of ATT may be of benefit to patients with suspected intraocular tuberculosis; however, this conclusion is limited by the lack of control group analysis and standardized recruitment and treatment protocols. We propose further prospective studies to better establish the efficacy of ATT and ascertain the factors associated with favorable treatment outcomes.
Competing Interests: There are no financial support and conflict of interest for any author.
(Copyright © 2016 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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