| Autor: |
Demicheli R; Scientific Directorate, Fondazione IRCCS Istituto Nazionale Tumori, 20133 Milano, Italy., Quiton DF; School of Public Health, University of South Carolina, Columbia, SC 29208, USA., Fornili M; Medical Statistics & Biometry, Università di Milano, 20133 Milano, Italy., Hrushesky WJ; School of Medicine, University of South Carolina, Columbia, SC 29209, USA. |
| Jazyk: |
angličtina |
| Zdroj: |
Future oncology (London, England) [Future Oncol] 2016 Mar; Vol. 12 (5), pp. 647-57. Date of Electronic Publication: 2016 Feb 01. |
| DOI: |
10.2217/fon.15.336 |
| Abstrakt: |
The profound scientific and commercial success of molecular biology, the progress of 'cancer gene' investigation technologies, together, pushed forward the postulate that genes explain 'everything'. Yet, during the last few years the microenvironments of solid tumors have emerged as key modulators of initiation, progression and metastasis and as essential to the therapeutic response. In the present review, we provide a synthetic examination of the main traits of cells embedded into the cancer stroma and emphasize several evidences that all components of the tumor tissue cooperate in space and time. Then we turn to discuss the epitheliocentric somatic mutational view and other new paradigms assuming that disturbed tissue interactions among cell populations are critical to cancer causation, growth and spread. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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