Cognitive Enhancement Therapy Improves Frontolimbic Regulation of Emotion in Alcohol and/or Cannabis Misusing Schizophrenia: A Preliminary Study.

Autor:	Wojtalik JA; School of Social Work, University of Pittsburgh , Pittsburgh, PA , USA., Hogarty SS; Department of Psychiatry, School of Medicine, University of Pittsburgh , Pittsburgh, PA , USA., Cornelius JR; Department of Psychiatry, School of Medicine, University of Pittsburgh , Pittsburgh, PA , USA., Phillips ML; Department of Psychiatry, School of Medicine, University of Pittsburgh , Pittsburgh, PA , USA., Keshavan MS; Department of Psychiatry, Harvard Medical School , Boston, MA , USA., Newhill CE; School of Social Work, University of Pittsburgh , Pittsburgh, PA , USA., Eack SM; School of Social Work, University of Pittsburgh, Pittsburgh, PA, USA; Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Jazyk:	angličtina
Zdroj:	Frontiers in psychiatry [Front Psychiatry] 2016 Jan 12; Vol. 6, pp. 186. Date of Electronic Publication: 2016 Jan 12 (Print Publication: 2015).
DOI:	10.3389/fpsyt.2015.00186
Abstrakt:	Individuals with schizophrenia who misuse substances are burdened with impairments in emotion regulation. Cognitive enhancement therapy (CET) may address these problems by enhancing prefrontal brain function. A small sample of outpatients with schizophrenia and alcohol and/or cannabis substance use problems participating in an 18-month randomized trial of CET (n = 10) or usual care (n = 4) completed posttreatment functional neuroimaging using an emotion regulation task. General linear models explored CET effects on brain activity in emotional neurocircuitry. Individuals treated with CET had significantly greater activation in broad regions of the prefrontal cortex, limbic, and striatal systems implicated in emotion regulation compared to usual care. Differential activation favoring CET in prefrontal regions and the insula mediated behavioral improvements in emotional processing. Our data lend preliminary support of CET effects on neuroplasticity in frontolimbic and striatal circuitries, which mediate emotion regulation in people with schizophrenia and comorbid substance misuse problems.
Databáze:	MEDLINE
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