Assessment of Background Parenchymal Enhancement and Lesion Kinetics in Breast MRI of BRCA 1/2 Mutation Carriers Compared to Matched Controls Using Quantitative Kinetic Analysis.

Autor:	Lewin AA; Department of Radiology, New York University School of Medicine, 660 First Avenue 4th floor, New York, New York 10016. Electronic address: Alana.Amarosa@nyumc.org., Kim SG; Department of Radiology, New York University School of Medicine, 660 First Avenue 4th floor, New York, New York 10016., Babb JS; Department of Radiology, New York University School of Medicine, 660 First Avenue 4th floor, New York, New York 10016., Melsaether AN; Department of Radiology, New York University School of Medicine, 660 First Avenue 4th floor, New York, New York 10016., McKellop J; Department of Radiology, New York University School of Medicine, 660 First Avenue 4th floor, New York, New York 10016., Moccaldi M; New York University Cancer Institute, 160 East 34th Street 2nd floor, New York, New York 10016., Klautau Leite AP; Department of Radiology, New York University School of Medicine, 660 First Avenue 4th floor, New York, New York 10016; Department of Radiology, Hospital das Clínicas, School of Medicine, University of São Paulo, São Paulo, SP, Brazil., Moy L; Department of Radiology, New York University School of Medicine, 660 First Avenue 4th floor, New York, New York 10016.
Jazyk:	angličtina
Zdroj:	Academic radiology [Acad Radiol] 2016 Mar; Vol. 23 (3), pp. 358-67. Date of Electronic Publication: 2016 Jan 07.
DOI:	10.1016/j.acra.2015.11.011
Abstrakt:	Rationale and Objectives: To investigate whether quantitative kinetic analysis of lesions and background parenchyma in breast magnetic resonance imaging can elucidate differences between BRCA carriers and sporadic controls with high risk for breast cancer. Materials and Methods: Fifty-nine BRCA and 59 control cases (49 benign, 10 malignant) were examined in this study. Principal component analysis was applied for quantitative analysis of dynamic signal in background parenchyma (B) and lesion (L) in terms of initial enhancement ratio (IER) and delayed enhancement ratio (DER). Results: Control B-IER, B-DER, L-IER, and L-DER were higher than BRCA cases in all women and in women with benign lesions; statistically significant differences in B-IER and B-DER (all women: P = 0.02 and P = 0.02, respectively; benign only: P = 0.005 and P = 0.005, respectively). In the control cohort, B-IER and B-DER were higher in the premenopausal women than in the postmenopausal women (P = 0.013 and 0.003, respectively), but not in the BRCA cohort; this led to significant differences in B-IER and B-DER between the control and the BRCA groups in the premenopausal women (P = 0.01 and 0.01, respectively) but not in the postmenopausal women. Conclusion: Results suggest possible differences in the vascular properties of background parenchyma between BRCA carriers and noncarriers and its association with menopausal status. (Copyright © 2015 The Association of University Radiologists. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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