IL-8 and IL-6 primarily mediate the inflammatory response in fibromyalgia patients.

Autor: Mendieta D; Clinical Service, National Institute of Psychiatry 'Ramón de la Fuente', Calzada México-Xochimilco 101, Col. San Lorenzo Huipulco, Tlalpan, 14370 Mexico City, DF, Mexico. Electronic address: danemend@hotmail.com., De la Cruz-Aguilera DL; Laboratory of Neuroimmunoendocrinology, National Institute of Neurology and Neurosurgery 'Manuel Velasco Suárez', Avenida Insurgentes Sur 3877, La Fama, Tlalpan, 14269 Mexico City, DF, Mexico. Electronic address: cruza_dl@hotmail.com., Barrera-Villalpando MI; Clinical Service, National Institute of Psychiatry 'Ramón de la Fuente', Calzada México-Xochimilco 101, Col. San Lorenzo Huipulco, Tlalpan, 14370 Mexico City, DF, Mexico. Electronic address: maribel_barrerav@yahoo.com.mx., Becerril-Villanueva E; Department of Psychoimmunology, National Institute of Psychiatry, 'Ramón de la Fuente', Calzada México-Xochimilco 101, Colonia San Lorenzo Huipulco, Tlalpan, 14370 Mexico City, DF, Mexico. Electronic address: lusenbeve@yahoo.com., Arreola R; Psychiatric Genetics Department, Clinical Research Branch, National Institute of Psychiatry, 'Ramón de la Fuente', Calzada México-Xochimilco 101, Colonia San Lorenzo Huipulco, Tlalpan, 14370 Mexico City, DF, Mexico. Electronic address: lahunsotz@yahoo.com.mx., Hernández-Ferreira E; Department of Psychoimmunology, National Institute of Psychiatry, 'Ramón de la Fuente', Calzada México-Xochimilco 101, Colonia San Lorenzo Huipulco, Tlalpan, 14370 Mexico City, DF, Mexico. Electronic address: erick.hdz.ferreira@gmail.com., Pérez-Tapia SM; Unit of R&D in Bioprocesses (UDIBI), National School of Biological Sciences, National Polytechnic Institute, Mexico City, Mexico; Unit of Research, Development and Innovation in Medicine and Biotechnology/Transfer Factor Project (UDIMEB/PFT), National School of Biological Sciences, National Polytechnic Institute, Mexico City, Mexico. Electronic address: smpt.2011@hotmail.com., Pérez-Sánchez G; Department of Psychoimmunology, National Institute of Psychiatry, 'Ramón de la Fuente', Calzada México-Xochimilco 101, Colonia San Lorenzo Huipulco, Tlalpan, 14370 Mexico City, DF, Mexico. Electronic address: gipersanchez@hotmail.com., Garcés-Alvarez ME; Department of Psychoimmunology, National Institute of Psychiatry, 'Ramón de la Fuente', Calzada México-Xochimilco 101, Colonia San Lorenzo Huipulco, Tlalpan, 14370 Mexico City, DF, Mexico; Unit of R&D in Bioprocesses (UDIBI), National School of Biological Sciences, National Polytechnic Institute, Mexico City, Mexico. Electronic address: me.garces.alvarez@live.com.mx., Aguirre-Cruz L; Laboratory of Neuroimmunoendocrinology, National Institute of Neurology and Neurosurgery 'Manuel Velasco Suárez', Avenida Insurgentes Sur 3877, La Fama, Tlalpan, 14269 Mexico City, DF, Mexico. Electronic address: mariluci_aguirre@hotmail.com., Velasco-Velázquez MA; School of Medicine, National Autonomous University of Mexico, Avenida Universidad 3000, Coyoacan, 04510 Mexico City, DF, Mexico. Electronic address: marcovelasco@unam.mx., Pavón L; Department of Psychoimmunology, National Institute of Psychiatry, 'Ramón de la Fuente', Calzada México-Xochimilco 101, Colonia San Lorenzo Huipulco, Tlalpan, 14370 Mexico City, DF, Mexico. Electronic address: lkuriaki@imp.edu.mx.
Jazyk: angličtina
Zdroj: Journal of neuroimmunology [J Neuroimmunol] 2016 Jan 15; Vol. 290, pp. 22-5. Date of Electronic Publication: 2015 Nov 26.
DOI: 10.1016/j.jneuroim.2015.11.011
Abstrakt: Fibromyalgia (FM) is a chronic disease that has been linked to inflammatory reactions and changes in the systemic levels of proinflammatory cytokines that modulate responses in the sympathetic nervous system and hypothalamic-pituitary-adrenal axis. We found that concentrations of IL-6 and IL-8 were elevated in FM patients. Both cytokines correlated with clinical scores, suggesting that IL-6 and IL-8 have additive or synergistic effects in perpetuating the chronic pain in FM patients. These findings indicate that IL-6 and IL-8 are two of the most constant inflammatory mediators in FM and that their levels correlate significantly with the severity of symptoms.
(Copyright © 2015 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: