Salicylic acid-based poly(anhydride-ester) nerve guidance conduits: Impact of localized drug release on nerve regeneration.

Autor: Lee YS; Department of Biomedical Engineering, Rutgers University, Piscataway, New Jersey 08854., Griffin J; Department of Biomedical Engineering, Rutgers University, Piscataway, New Jersey 08854., Masand SN; Department of Biomedical Engineering, Rutgers University, Piscataway, New Jersey 08854., Shreiber DI; Department of Biomedical Engineering, Rutgers University, Piscataway, New Jersey 08854., Uhrich KE; Department of Biomedical Engineering, Rutgers University, Piscataway, New Jersey 08854.; Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, New Jersey, 08854.
Jazyk: angličtina
Zdroj: Journal of biomedical materials research. Part A [J Biomed Mater Res A] 2016 Apr; Vol. 104 (4), pp. 975-82. Date of Electronic Publication: 2016 Jan 20.
DOI: 10.1002/jbm.a.35630
Abstrakt: Nerve guidance conduits (NGCs) can serve as physical scaffolds aligning and supporting regenerating cells while preventing scar tissue formation that often interferes with the regeneration process. Numerous studies have focused on functionalizing NGCs with neurotrophic factors, for example, to support nerve regeneration over longer gaps, but few directly incorporate therapeutic agents. Herein, we fabricated NGCs from a polyanhydride comprised of salicylic acid (SA), a nonsteroidal anti-inflammatory drug, then performed in vitro and in vivo assays. In vitro studies included cytotoxicity, anti-inflammatory response, and NGC porosity measurements. To prepare for implantation, type I collagen hydrogels were used as NGC luminal fillers to further enhance the axonal regeneration process. For the in vivo studies, SA-NGCs were implanted in femoral nerves of mice for 16 weeks and evaluated for functional recovery. The SA-based NGCs functioned as both a drug delivery vehicle capable of reducing inflammation and scar tissue formation because of SA release as well as a tissue scaffold that promotes peripheral nerve regeneration and functional recovery.
(© 2016 Wiley Periodicals, Inc.)
Databáze: MEDLINE
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