Effects of the M1 muscarinic antagonist dicyclomine on emotional memory retrieval.
| Autor: | Soares JC; Department of Psychobiology, Universidade Federal de São Paulo (UNIFESP)., Perfetto JG; Department of Psychobiology, Universidade Federal de São Paulo (UNIFESP)., Antonio BB; Department of Psychobiology, Universidade Federal de São Paulo (UNIFESP)., Oliveira MG; Department of Psychobiology, Universidade Federal de São Paulo (UNIFESP). |
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| Jazyk: | angličtina |
| Zdroj: | Behavioral neuroscience [Behav Neurosci] 2016 Feb; Vol. 130 (1), pp. 29-35. Date of Electronic Publication: 2015 Nov 30. |
| DOI: | 10.1037/bne0000113 |
| Abstrakt: | Extensive research has shown the involvement of the central cholinergic system in the acquisition and consolidation of tasks involving conditioned fear responses, such as those observed in contextual fear conditioning (CFC), tone fear conditioning (TFC) and inhibitory avoidance (IA). However, there are few data concerning the role of this system in the memory retrieval process. Therefore, the present study aimed to compare the effects of the administration of an M1 antagonist on retrieval during these tasks. For each behavioral procedure, groups of male Wistar rats were trained. Twenty-four hr later, they were treated with different doses of dicyclomine (16, 32, or 64 mg/kg, i.p.) or with saline 30 min before the test session. The results showed that dicyclomine at doses of 16 and 32 mg/kg impaired CFC without interfering with IA performance. Moreover, only 64 mg/kg impaired TFC. These data suggest that M1 muscarinic receptors contribute to memory retrieval in CFC and TFC but are not essential for retrieval in IA. ((c) 2016 APA, all rights reserved).) |
| Databáze: | MEDLINE |
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