Assessment of serum magnesium levels and its outcome in neonates of eclamptic mothers treated with low-dose magnesium sulfate regimen.

Autor: Das M; Department of Pharmacology, College of Medicine and Sagore Dutta Hospital, Kamarhati, West Bengal, India., Chaudhuri PR; Department of Pharmacology, Calcutta National Medical College, Berhampur, West Bengal, India., Mondal BC; Department of Paediatric Medicine, Murshidabad Medical College, Berhampur, West Bengal, India., Mitra S; Department of Obstetrics and Gynaecology, Medical College, Kolkata, West Bengal, India., Bandyopadhyay D; Department of Biochemistry, Burdwan Medical College, Burdwan, West Bengal, India., Pramanik S; Department of Pharmacology, Calcutta National Medical College, Berhampur, West Bengal, India.
Jazyk: angličtina
Zdroj: Indian journal of pharmacology [Indian J Pharmacol] 2015 Sep-Oct; Vol. 47 (5), pp. 502-8.
DOI: 10.4103/0253-7613.165183
Abstrakt: Objectives: Magnesium historically has been used for treatment and/or prevention of eclampsia. Considering the low body mass index of Indian women, a low-dose magnesium sulfate regime has been introduced by some authors. Increased blood levels of magnesium in neonates is associated with increased still birth, early neonatal death, birth asphyxia, bradycardia, hypotonia, gastrointestinal hypomotility. The objective of this study was to assess safety of low-dose magnesium sulfate regimen in neonates of eclamptic mothers treated with this regimen.
Materials and Methods: This was a cross-sectional observational study of 100 eclampsia patients and their neonates. Loading dose and maintenance doses of magnesium sulfate were administered to patients by combination of intravenous and intramuscular routes. Maternal serum and cord blood magnesium levels were estimated. Neonatal outcome was assessed.
Results: Bradycardia was observed in 18 (19.15%) of the neonates, 16 (17.02%) of the neonates were diagnosed with hypotonia. Pearson Correlation Coefficient showed Apgar scores decreased with increase in cord blood magnesium levels. Unpaired t-test showed lower Apgar scores with increasing dose of magnesium sulfate. The Chi-square/Fisher's exact test showed significant increase in hypotonia, birth asphyxia, intubation in delivery room, Neonatal Intensive Care Unit (NICU) care requirement, with increasing dose of magnesium sulfate. (P ≤ 0.05).
Conclusion: Several neonatal complications are significantly related to increasing serum magnesium levels. Overall, the low-dose magnesium sulfate regimen was safe in the management of eclamptic mothers, without toxicity to their neonates.
Databáze: MEDLINE
Externí odkaz: