Increased chemerin and decreased omentin-1 levels in morbidly obese patients are correlated with insulin resistance, oxidative stress and chronic inflammation.

Autor: Cătoi AF; Department of Physiology, Faculty of Medicine, 'Iuliu Haţieganu' University of Medicine and Pharmacy Cluj-Napoca, Romania., Suciu Ş; Department of Physiology, Faculty of Medicine, 'Iuliu Haţieganu' University of Medicine and Pharmacy Cluj-Napoca, Romania., Pârvu AE; Department of Pathophysiology, Faculty of Medicine, 'Iuliu Haţieganu' University of Medicine and Pharmacy Cluj-Napoca, Romania., Copăescu C; Bariatric Center of Excellence (BariXL) 'Ponderas' (Delta) Hospital, Bucharest, Romania., Galea RF; Second Surgical Clinic, Faculty of Medicine, 'Iuliu Haţieganu' University of Medicine and Pharmacy Cluj-Napoca, Romania., Buzoianu AD; Department of Pharmacology, Faculty of Medicine 'Iuliu Haţieganu' University of Medicine and Pharmacy Cluj-Napoca, Romania., Vereşiu IA; Clinical Center of Diabetes, Faculty of Medicine, 'Iuliu Haţieganu' University of Medicine and Pharmacy Cluj-Napoca, Romania., Cătoi C; Department of Pathology, Faculty of Veterinary Medicine, University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca, Romania., Pop ID; Department of Exact Sciences, Faculty of Horticulture, University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca, Romania.
Jazyk: angličtina
Zdroj: Clujul medical (1957) [Clujul Med] 2014; Vol. 87 (1), pp. 19-26. Date of Electronic Publication: 2014 Jan 30.
DOI: 10.15386/cjm.2014.8872.871.afc1
Abstrakt: Background and Aim: Morbid obesity represents a proinflammatory and pro-oxidative state associated with dysregulation of adipokines. We aimed to evaluate the circulating levels of chemerin and omentin-1 in morbidly obese (MO) patients and to investigate the relationship between these two adipokines and between each of them and anthropometric, metabolic, oxidative stress and chronic inflammatory parameters.
Material and Methods: 32 MO patients and 20 controls were investigated in this study. Anthropometric, metabolism parameters, inflammatory markers, oxidative stress indicators as well as chemerin and omentin-1 were measured.
Results: Serum levels of chemerin were increased while omentin-1 levels were decreased in MO patients when compared with controls. Chemerin correlated positively with insulin, HOMA-IR, LDL cholesterol and negatively with total antioxidant response. Omentin-1 correlated negatively with tumor necrosis factor alpha and total cholesterol. In a multiple linear stepwise regression analysis we learnt that only HOMA-IR (β=0.70, p<0.001), total cholesterol (β=0.42, p<0.001) and triglycerides (β=0.31, p<0.05) remained significantly associated with chemerin changes. Using the same analysis we noticed that total cholesterol (β=-0.71, p<0.001), fasting glucose (β= -0.40, p<0.05) and body mass index (BMI) (β= -0.38, p<0.05) were considered to be significant predictors for omentin-1 changes.
Conclusions: Chemerin and omentin-1 synthesis was dysregulated in MO patients. Chemerin might play a role in insulin resistance and oxidative stress. Chemerin changes seemed to be predicted mainly by insulin resistance. Omentin-1 levels were inversely associated with chronic inflammation and dyslipidemia while the main modulating factors seemed to be dyslipidemia, hyperglycemia and BMI.
Databáze: MEDLINE
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