A brain circuit that synchronizes growth and maturation revealed through Dilp8 binding to Lgr3.
| Autor: | Vallejo DM; Instituto de Neurociencias, Consejo Superior de Investigaciones Cientifícas and Universidad Miguel Hernández, Campus de Sant Joan, Apartado 18, 03550 Sant Joan, Alicante, Spain., Juarez-Carreño S; Instituto de Neurociencias, Consejo Superior de Investigaciones Cientifícas and Universidad Miguel Hernández, Campus de Sant Joan, Apartado 18, 03550 Sant Joan, Alicante, Spain., Bolivar J; Departamento de Biomedicina, Biotecnología y Salud Pública, Facultad de Ciencias, Universidad de Cadiz, Poligono Rio San Pedro s/n, 11510 Puerto Real, Spain., Morante J; Instituto de Neurociencias, Consejo Superior de Investigaciones Cientifícas and Universidad Miguel Hernández, Campus de Sant Joan, Apartado 18, 03550 Sant Joan, Alicante, Spain. m.dominguez@umh.es j.morante@umh.es., Dominguez M; Instituto de Neurociencias, Consejo Superior de Investigaciones Cientifícas and Universidad Miguel Hernández, Campus de Sant Joan, Apartado 18, 03550 Sant Joan, Alicante, Spain. m.dominguez@umh.es j.morante@umh.es. |
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| Jazyk: | angličtina |
| Zdroj: | Science (New York, N.Y.) [Science] 2015 Nov 13; Vol. 350 (6262), pp. aac6767. Date of Electronic Publication: 2015 Oct 01. |
| DOI: | 10.1126/science.aac6767 |
| Abstrakt: | Body-size constancy and symmetry are signs of developmental stability. Yet, it is unclear exactly how developing animals buffer size variation. Drosophila insulin-like peptide Dilp8 is responsive to growth perturbations and controls homeostatic mechanisms that coordinately adjust growth and maturation to maintain size within the normal range. Here we show that Lgr3 is a Dilp8 receptor. Through the use of functional and adenosine 3',5'-monophosphate assays, we defined a pair of Lgr3 neurons that mediate homeostatic regulation. These neurons have extensive axonal arborizations, and genetic and green fluorescent protein reconstitution across synaptic partners show that these neurons connect with the insulin-producing cells and prothoracicotropic hormone-producing neurons to attenuate growth and maturation. This previously unrecognized circuit suggests how growth and maturation rate are matched and co-regulated according to Dilp8 signals to stabilize organismal size. (Copyright © 2015, American Association for the Advancement of Science.) |
| Databáze: | MEDLINE |
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