Exercise and Cyclic Light Preconditioning Protect Against Light-Induced Retinal Degeneration and Evoke Similar Gene Expression Patterns.

Autor: Chrenek MA; Department of Ophthalmology, Emory University School of Medicine, Room B5500, Emory Eye Center, 1365B, Clifton Road, N.E., 30322, Atlanta, GA, USA. mchrene@emory.edu., Sellers JT; Department of Ophthalmology, Emory University School of Medicine, Room B5500, Emory Eye Center, 1365B, Clifton Road, N.E., 30322, Atlanta, GA, USA. jana.t.sellers@emory.edu., Lawson EC; Department of Ophthalmology, Emory University School of Medicine, Room B5500, Emory Eye Center, 1365B, Clifton Road, N.E., 30322, Atlanta, GA, USA. eric.lawson90@gmail.com.; Atlanta VA Center of Excellence for Visual and Neurocognitive Rehabilitation, Atlanta VA Medical Center, 30033, Decatur, GA, USA. eric.lawson90@gmail.com., Cunha PP; Department of Ophthalmology, Emory University School of Medicine, Room B5500, Emory Eye Center, 1365B, Clifton Road, N.E., 30322, Atlanta, GA, USA. priscila.cunha@emory.edu., Johnson JL; Department of Ophthalmology, Emory University School of Medicine, Room B5500, Emory Eye Center, 1365B, Clifton Road, N.E., 30322, Atlanta, GA, USA. Jessica.johnson@emory.edu., Girardot PE; Department of Ophthalmology, Emory University School of Medicine, Room B5500, Emory Eye Center, 1365B, Clifton Road, N.E., 30322, Atlanta, GA, USA. preston.girardot@emory.edu., Kendall C; Department of Ophthalmology, Emory University School of Medicine, Room B5500, Emory Eye Center, 1365B, Clifton Road, N.E., 30322, Atlanta, GA, USA. cristina.kendall@gmail.com., Han MK; Department of Ophthalmology, Emory University School of Medicine, Room B5500, Emory Eye Center, 1365B, Clifton Road, N.E., 30322, Atlanta, GA, USA. zlalunar@hotmail.com.; Atlanta VA Center of Excellence for Visual and Neurocognitive Rehabilitation, Atlanta VA Medical Center, 30033, Decatur, GA, USA. zlalunar@hotmail.com., Hanif A; Department of Ophthalmology, Emory University School of Medicine, Room B5500, Emory Eye Center, 1365B, Clifton Road, N.E., 30322, Atlanta, GA, USA. ahanif@emory.edu.; Atlanta VA Center of Excellence for Visual and Neurocognitive Rehabilitation, Atlanta VA Medical Center, 30033, Decatur, GA, USA. ahanif@emory.edu., Ciavatta VT; Department of Ophthalmology, Emory University School of Medicine, Room B5500, Emory Eye Center, 1365B, Clifton Road, N.E., 30322, Atlanta, GA, USA. vciavat@emory.edu.; Atlanta VA Center of Excellence for Visual and Neurocognitive Rehabilitation, Atlanta VA Medical Center, 30033, Decatur, GA, USA. vciavat@emory.edu., Gogniat MA; Department of Ophthalmology, Emory University School of Medicine, Room B5500, Emory Eye Center, 1365B, Clifton Road, N.E., 30322, Atlanta, GA, USA. mgognia@emory.edu.; Atlanta VA Center of Excellence for Visual and Neurocognitive Rehabilitation, Atlanta VA Medical Center, 30033, Decatur, GA, USA. mgognia@emory.edu., Nickerson JM; Department of Ophthalmology, Emory University School of Medicine, Room B5500, Emory Eye Center, 1365B, Clifton Road, N.E., 30322, Atlanta, GA, USA. litjn@emory.edu., Pardue MT; Department of Ophthalmology, Emory University School of Medicine, Room B5500, Emory Eye Center, 1365B, Clifton Road, N.E., 30322, Atlanta, GA, USA. mpardue@emory.edu.; Atlanta VA Center of Excellence for Visual and Neurocognitive Rehabilitation, Atlanta VA Medical Center, 30033, Decatur, GA, USA. mpardue@emory.edu., Boatright JH; Department of Ophthalmology, Emory University School of Medicine, Room B5500, Emory Eye Center, 1365B, Clifton Road, N.E., 30322, Atlanta, GA, USA. jboatri@emory.edu.; Atlanta VA Center of Excellence for Visual and Neurocognitive Rehabilitation, Atlanta VA Medical Center, 30033, Decatur, GA, USA. jboatri@emory.edu.
Jazyk: angličtina
Zdroj: Advances in experimental medicine and biology [Adv Exp Med Biol] 2016; Vol. 854, pp. 443-8.
DOI: 10.1007/978-3-319-17121-0_59
Abstrakt: To compare patterns of gene expression following preconditioning cyclic light rearing versus preconditioning aerobic exercise. BALB/C mice were preconditioned either by rearing in 800 lx 12:12 h cyclic light for 8 days or by running on treadmills for 9 days, exposed to toxic levels of light to cause light-induced retinal degeneration (LIRD), then sacrificed and retinal tissue harvested. Subsets of mice were maintained for an additional 2 weeks and for assessment of retinal function by electroretinogram (ERG). Both preconditioning protocols partially but significantly preserved retinal function and morphology and induced similar leukemia inhibitory factor (LIF) gene expression pattern. The data demonstrate that exercise preconditioning and cyclic light preconditioning protect photoreceptors against LIRD and evoke a similar pattern of retinal LIF gene expression. It may be that similar stress response pathways mediate the protection provided by the two preconditioning modalities.
Databáze: MEDLINE