| Autor: |
Chandel RS; Junior Resident, Department of Biochemistry, Grant Government Medical College and Sir J.J. Group of Hospitals , Mumbai, India., Roy A; Junior Resident, Department of Biochemistry, Grant Government Medical College and Sir J.J. Group of Hospitals , Mumbai, India., Abichandani LG; Professor, Department of Biochemistry, Grant Government Medical College and Sir J.J. Group of Hospitals , Mumbai, India . |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of clinical and diagnostic research : JCDR [J Clin Diagn Res] 2015 Jul; Vol. 9 (7), pp. BD01-2. Date of Electronic Publication: 2015 Jul 01. |
| DOI: |
10.7860/JCDR/2015/11771.6142 |
| Abstrakt: |
Haemoglobin D is a rare form of haemoglobinopathy in homozygous form. However, the heterozygous form of the disease is clinically silent and relatively easier to find in North-West India, Pakistan and Iran. Haemoglobin D is sometimes found to be coexistent with Haemoglobin S and/or Thalassaemia leading to clinically significant conditions like sickle cell anaemia with mild to moderate splenomegaly. In India the more prevalent form is Haemoglobin D-Punjab (also known as Hb D- Los Angeles) which has a prevalence of 2% in Punjab and around 1% in Gujarat. However, the variant, Haemoglobin D- Iran is very rare in India in heterozygous as well as homozygous forms. This report is of a 36-year-old female, who visited for an antenatal check up. On analysing the blood sample using Agarose Gel Electrophoresis in Alkaline media, the migration of abnormal haemoglobin to haemoglobin S/D/G region was observed. Sickle cell solubility test was negative. On capillary electrophoresis, peak in the Haemoglobin D Zone was seen. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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