Adrenal gland volume assessed by magnetic resonance imaging in women with polycystic ovary syndrome.

Autor: Unlu E; Afyon Kocatepe University, School of Medicine, Department of Radiology, Izmir yolu 7.km, Afyonkarahisar, Turkey. Electronic address: edunlu@yahoo.com., Unlu BS; Afyon Kocatepe University, School of Medicine, Department of Obstetrics and Gynecology, Afyonkarahisar, Turkey., Yildiz Y; Clinic of Obstetrics and Gynecology, Ilgin State Hospital, Konya, Turkey., Beker-Acay M; Afyon Kocatepe University, School of Medicine, Department of Radiology, Izmir yolu 7.km, Afyonkarahisar, Turkey., Kacar E; Afyon Kocatepe University, School of Medicine, Department of Radiology, Izmir yolu 7.km, Afyonkarahisar, Turkey., Turamanlar O; Afyon Kocatepe University, School of Medicine, Department of Anatomy, Afyonkarahisar, Turkey., Tulmac OB; Kirikkale University, School of Medicine, Department of Obstetrics and Gynecology, Kirikkale, Turkey., Seven A; Dumlupinar University, School of Medicine, Department of Obstetrics and Gynecology, Kutahya, Turkey., Ozuguz U; Afyon Kocatepe University, School of Medicine, Department of Endocrinology and Metabolism, Afyonkarahisar, Turkey.
Jazyk: angličtina
Zdroj: Diagnostic and interventional imaging [Diagn Interv Imaging] 2016 Jan; Vol. 97 (1), pp. 57-63. Date of Electronic Publication: 2015 Sep 08.
DOI: 10.1016/j.diii.2015.02.004
Abstrakt: Purpose: To determine adrenal gland volume (AGV) in women with polycystic ovary syndrome (PCOS) by comparison with healthy control subjects and to investigate the relationship between AGV and hormonal status.
Patients and Methods: AGV was measured on transverse sections of T1-weighted MRI imaging data in 27 PCOS patients and 40 age-matched control subjects for this prospectively designed study. A comparative analysis of AGV in PCOS and controls was performed and possible correlations between AGV and hormonal parameters were evaluated.
Results: PCOS patients had significantly larger AGV compared to controls ((11.7±4.4 cm(3), 7.2±1.9 cm(3), respectively, P<0.001). A significant positive correlation was found between total AGV and dehydroepiandrosterone sulfate, 17-OH progesterone, and total and free testosterone levels in the PCOS group (r=+0.51, +0.48, +0.43, +0.62, respectively; P values<0.05). In addition, AGV was significantly negatively correlated with LH and LH/FSH ratio in the PCOS group (r= -0.55, P=0.02; r=-0.51, P=0.01, respectively).
Conclusions: PCOS patients have significantly increased AGV as well as a positive correlation of AGV and androgens. We conclude that the assessment of AGV with MRI shows a significant correlation with the androgenic activity of the gland, and that hypertrophy of the adrenal gland may be involved in the pathogenesis of PCOS.
(Copyright © 2015 Éditions françaises de radiologie. Published by Elsevier Masson SAS. All rights reserved.)
Databáze: MEDLINE
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