Behavioural and psychological symptoms of dementia in Down syndrome: Early indicators of clinical Alzheimer's disease?

Autor: Dekker AD; Department of Neurology and Alzheimer Research Center, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; Laboratory of Neurochemistry and Behaviour, Institute Born-Bunge, University of Antwerp, Wilrijk, Antwerp, Belgium. Electronic address: a.d.dekker@umcg.nl., Strydom A; Division of Psychiatry, University College London, London, United Kingdom. Electronic address: a.strydom@ucl.ac.uk., Coppus AM; Department for Primary and Community Care, Radboud University Medical Center, Nijmegen, The Netherlands. Electronic address: Tonnie.Coppus@radboudumc.nl., Nizetic D; The Blizard Institute, Barts and The London School of Medicine, Queen Mary University of London, London, United Kingdom; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore. Electronic address: d.nizetic@qmul.ac.uk., Vermeiren Y; Laboratory of Neurochemistry and Behaviour, Institute Born-Bunge, University of Antwerp, Wilrijk, Antwerp, Belgium. Electronic address: yannick.vermeiren@uantwerpen.be., Naudé PJ; Department of Neurology and Alzheimer Research Center, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. Electronic address: p.j.w.naude@umcg.nl., Van Dam D; Department of Neurology and Alzheimer Research Center, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; Laboratory of Neurochemistry and Behaviour, Institute Born-Bunge, University of Antwerp, Wilrijk, Antwerp, Belgium. Electronic address: debby.vandam@uantwerpen.be., Potier MC; Sorbonne Universités, UPMC Univ Paris 06, Inserm, CNRS, UM 75, U 1127, UMR 7225, ICM, Paris, France. Electronic address: marie-claude.potier@upmc.fr., Fortea J; Catalan Down Syndrome Foundation and Department of Neurology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain. Electronic address: jfortea@santpau.cat., De Deyn PP; Department of Neurology and Alzheimer Research Center, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; Laboratory of Neurochemistry and Behaviour, Institute Born-Bunge, University of Antwerp, Wilrijk, Antwerp, Belgium. Electronic address: p.p.de.deyn@umcg.nl.
Jazyk: angličtina
Zdroj: Cortex; a journal devoted to the study of the nervous system and behavior [Cortex] 2015 Dec; Vol. 73, pp. 36-61. Date of Electronic Publication: 2015 Aug 13.
DOI: 10.1016/j.cortex.2015.07.032
Abstrakt: Behavioural and Psychological Symptoms of Dementia (BPSD) are a core symptom of dementia and are associated with suffering, earlier institutionalization and accelerated cognitive decline for patients and increased caregiver burden. Despite the extremely high risk for Down syndrome (DS) individuals to develop dementia due to Alzheimer's disease (AD), BPSD have not been comprehensively assessed in the DS population. Due to the great variety of DS cohorts, diagnostic methodologies, sub-optimal scales, covariates and outcome measures, it is questionable whether BPSD have always been accurately assessed. However, accurate recognition of BPSD may increase awareness and understanding of these behavioural aberrations, thus enabling adaptive caregiving and, importantly, allowing for therapeutic interventions. Particular BPSD can be observed (long) before the clinical dementia diagnosis and could therefore serve as early indicators of those at risk, and provide a new, non-invasive way to monitor, or at least give an indication of, the complex progression to dementia in DS. Therefore, this review summarizes and evaluates the rather limited knowledge on BPSD in DS and highlights its importance and potential for daily clinical practice.
(Copyright © 2015 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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